Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 703367..704202 Replicon chromosome
Accession NZ_CP096118
Organism Salmonella enterica subsp. enterica serovar Indiana strain 22

Toxin (Protein)


Gene name yeeV Uniprot ID A0A763DSF8
Locus tag MZK41_RS03430 Protein ID WP_047928871.1
Coordinates 703825..704202 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag MZK41_RS03425 Protein ID WP_047928872.1
Coordinates 703367..703735 (+) Length 123 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MZK41_RS03400 (700483) 700483..701301 + 819 WP_001234702.1 DUF932 domain-containing protein -
MZK41_RS03405 (701392) 701392..701877 + 486 WP_000214316.1 antirestriction protein -
MZK41_RS03410 (701892) 701892..702368 + 477 WP_148251817.1 RadC family protein -
MZK41_RS03415 (702437) 702437..702658 + 222 WP_000692353.1 DUF987 domain-containing protein -
MZK41_RS03420 (702673) 702673..703317 + 645 WP_101975700.1 antitoxin of toxin-antitoxin stability system -
MZK41_RS03425 (703367) 703367..703735 + 369 WP_047928872.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MZK41_RS03430 (703825) 703825..704202 + 378 WP_047928871.1 TA system toxin CbtA family protein Toxin
MZK41_RS03435 (704199) 704199..704348 + 150 Protein_673 DUF5983 family protein -
MZK41_RS03440 (704424) 704424..704621 + 198 WP_096093965.1 DUF957 domain-containing protein -
MZK41_RS03445 (704706) 704706..705551 + 846 WP_072650597.1 DUF4942 domain-containing protein -
MZK41_RS03450 (705553) 705553..705810 - 258 WP_248114753.1 hypothetical protein -
MZK41_RS03455 (705810) 705810..706823 - 1014 WP_015386347.1 tyrosine-type recombinase/integrase -
MZK41_RS03460 (707050) 707050..707664 - 615 WP_015386349.1 phage repressor protein CI -
MZK41_RS03465 (707766) 707766..708002 + 237 WP_015386350.1 hypothetical protein -
MZK41_RS03470 (708037) 708037..708546 + 510 WP_015386351.1 phage regulatory CII family protein -
MZK41_RS03475 (708554) 708554..708754 + 201 WP_015386352.1 DUF2724 domain-containing protein -
MZK41_RS03480 (708718) 708718..709059 + 342 WP_000963477.1 DUF5347 domain-containing protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - rfaE 701392..752471 51079


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-112)

Antitoxin

(18-117)


Sequences


Toxin        


Download         Length: 126 a.a.        Molecular weight: 13941.88 Da        Isoelectric Point: 7.3222

>T242747 WP_047928871.1 NZ_CP096118:703825-704202 [Salmonella enterica subsp. enterica serovar Indiana]
MKTLPVLPGQAAGSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
STCTHSQLINSIDILRARRATGLMTRDNYRTVNGITQGKHPEAKQ

Download         Length: 378 bp

>T242747 NZ_OW967178:2092737-2092840 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13757.47 Da        Isoelectric Point: 5.0907

>AT242747 WP_047928872.1 NZ_CP096118:703367-703735 [Salmonella enterica subsp. enterica serovar Indiana]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEDNQLHYLADRAGIRGRFSDADAYHLDQALPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT242747 NZ_OW967178:c2092878-2092607 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A763DSF8


Antitoxin

Source ID Structure

References