Detailed information of TA system TA242724

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 665243..665802
• Replicon: chromosome
• Accession: NZ_CP096035
• Organism: Rhodococcus pyridinivorans strain Y6

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: MX572_RS03260
• Protein ID: WP_024102981.1
• Coordinates: 665524..665802 (+)
• Length: 93 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: MX572_RS03255
• Protein ID: WP_024102980.1
• Coordinates: 665243..665527 (+)
• Length: 95 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MX572_RS03230 (MX572_03230)	660440..661072	+	633	WP_006551862.1	TetR/AcrR family transcriptional regulator	-
MX572_RS03235 (MX572_03235)	661069..661497	+	429	WP_064255976.1	HIT family protein	-
MX572_RS03240 (MX572_03240)	661502..663103	+	1602	WP_024102976.1	L-lactate permease	-
MX572_RS03245 (MX572_03245)	663180..664208	+	1029	WP_064255975.1	Dyp-type peroxidase	-
MX572_RS03250 (MX572_03250)	664205..665023	+	819	WP_006551857.1	family 1 encapsulin nanocompartment shell protein	-
MX572_RS03255 (MX572_03255)	665243..665527	+	285	WP_024102980.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MX572_RS03260 (MX572_03260)	665524..665802	+	279	WP_024102981.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MX572_RS03265 (MX572_03265)	665859..666338	-	480	WP_039585875.1	MarR family transcriptional regulator	-
MX572_RS03270 (MX572_03270)	666397..667146	-	750	WP_024102983.1	cutinase family protein	-
MX572_RS03275 (MX572_03275)	667296..667958	-	663	WP_094979476.1	alpha-ketoglutarate-dependent dioxygenase AlkB	-
MX572_RS03280 (MX572_03280)	668079..668909	+	831	WP_254583723.1	SDR family oxidoreductase	-
MX572_RS03285 (MX572_03285)	668954..669925	+	972	WP_006551850.1	phosphotriesterase	-
MX572_RS03290 (MX572_03290)	669962..670681	-	720	WP_041803971.1	2OG-Fe(II) oxygenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (34-91)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 93 a.a.
• Molecular weight: 10268.82 Da
• Isoelectric Point: 10.2002

>T242724 WP_024102981.1 NZ_CP096035:665524-665802 [Rhodococcus pyridinivorans]
MSTPDHPYRLVMARSAARAMARSLPEKVATAVYEFVTGPLLENPKRVGKPLNPPLAPAYSARRGEYRVLYLIDDANRTVE
VTAISHRADAYR

Nucleotide

• Length: 279 bp

>T242724 NZ_OW967003:1457960-1458346 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGTAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin

Protein

• Length: 95 a.a.
• Molecular weight: 10494.56 Da
• Isoelectric Point: 4.2336

>AT242724 WP_024102980.1 NZ_CP096035:665243-665527 [Rhodococcus pyridinivorans]
MTTLPVADARAQLSRLVDEAERTHERFEITRNGHRAAVLLGADDYDAMQETIAVLSDTDLLRAHVEGRTEVESGDVVDVQ
ELTQLMRDARSSEE

Nucleotide

• Length: 285 bp

>AT242724 NZ_OW967003:1458336-1458665 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA