Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | higBA (relBE)/HigB-HigA |
| Location | 2294387..2295114 | Replicon | chromosome |
| Accession | NZ_CP095856 | ||
| Organism | Escherichia coli strain EC6563 | ||
Toxin (Protein)
| Gene name | higB | Uniprot ID | - |
| Locus tag | MYG04_RS11125 | Protein ID | WP_108429971.1 |
| Coordinates | 2294800..2295114 (-) | Length | 105 a.a. |
Antitoxin (Protein)
| Gene name | higA | Uniprot ID | - |
| Locus tag | MYG04_RS11120 | Protein ID | WP_000560266.1 |
| Coordinates | 2294387..2294803 (-) | Length | 139 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MYG04_RS11110 (2289547) | 2289547..2291898 | + | 2352 | WP_000695502.1 | alpha-glucosidase | - |
| MYG04_RS11115 (2292324) | 2292324..2294342 | + | 2019 | WP_000121449.1 | NADPH-dependent 2,4-dienoyl-CoA reductase | - |
| MYG04_RS11120 (2294387) | 2294387..2294803 | - | 417 | WP_000560266.1 | type II toxin-antitoxin system antitoxin HigA | Antitoxin |
| MYG04_RS11125 (2294800) | 2294800..2295114 | - | 315 | WP_108429971.1 | type II toxin-antitoxin system toxin HigB | Toxin |
| MYG04_RS11130 (2295398) | 2295398..2296534 | - | 1137 | WP_000018695.1 | 23S rRNA (guanine(1835)-N(2))-methyltransferase RlmG | - |
| MYG04_RS11135 (2296619) | 2296619..2297122 | + | 504 | WP_001300832.1 | M48 family metallopeptidase | - |
| MYG04_RS11140 (2297199) | 2297199..2297891 | + | 693 | WP_000942546.1 | vancomycin high temperature exclusion protein | - |
| MYG04_RS11145 (2297970) | 2297970..2298956 | + | 987 | WP_001301393.1 | Gfo/Idh/MocA family oxidoreductase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 105 a.a. Molecular weight: 12054.03 Da Isoelectric Point: 10.1027
>T242644 WP_108429971.1 NZ_CP095856:c2295114-2294800 [Escherichia coli]
MHLITQKALKDAAEKNPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
MHLITQKALKDAAEKNPQHKTELVALGNTIAKGYFKKPESLKAVFPSLDNFKYLDKHYVFNVGGNELRVVAMVFFESQKC
YIREVMTHKEYDFFTAVHRTKGKK
Download Length: 315 bp
>T242644 NZ_OW849082:2173420-2173523 [Citrobacter freundii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT
Antitoxin
Download Length: 139 a.a. Molecular weight: 14995.42 Da Isoelectric Point: 4.4547
>AT242644 WP_000560266.1 NZ_CP095856:c2294803-2294387 [Escherichia coli]
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
MIAIADILQAGEKLTAVAPFLAGIQNEEQYTQALELVDHLLLNDPENPLLDLVCAKITAWEESAPEFAEFNAMAQAMPGG
IAVIRTLMDQYGLTLSDLPEIGSKSMVSRVLSGKRKLTLEHAKKLATRFGISPALFID
Download Length: 417 bp
>AT242644 NZ_OW849082:c2173528-2173385 [Citrobacter freundii]
CACATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT
CACATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|