Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 2232426..2233267 | Replicon | chromosome |
| Accession | NZ_CP095856 | ||
| Organism | Escherichia coli strain EC6563 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A1M0WJM1 |
| Locus tag | MYG04_RS10835 | Protein ID | WP_000854822.1 |
| Coordinates | 2232426..2232809 (-) | Length | 128 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A1M0CWL2 |
| Locus tag | MYG04_RS10840 | Protein ID | WP_053271974.1 |
| Coordinates | 2232899..2233267 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MYG04_RS10805 (2228071) | 2228071..2229912 | + | 1842 | WP_000437375.1 | RNA polymerase sigma factor RpoD | - |
| MYG04_RS10810 (2229991) | 2229991..2230497 | - | 507 | WP_000228937.1 | G/U mismatch-specific DNA glycosylase | - |
| MYG04_RS10820 (2230796) | 2230796..2231641 | - | 846 | WP_001280435.1 | DUF4942 domain-containing protein | - |
| MYG04_RS10825 (2231738) | 2231738..2231935 | - | 198 | WP_000839263.1 | DUF957 domain-containing protein | - |
| MYG04_RS10830 (2231947) | 2231947..2232435 | - | 489 | WP_001177592.1 | DUF5983 family protein | - |
| MYG04_RS10835 (2232426) | 2232426..2232809 | - | 384 | WP_000854822.1 | type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA | Toxin |
| MYG04_RS10840 (2232899) | 2232899..2233267 | - | 369 | WP_053271974.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| MYG04_RS10845 (2233347) | 2233347..2233568 | - | 222 | WP_000692312.1 | DUF987 domain-containing protein | - |
| MYG04_RS10850 (2233637) | 2233637..2234113 | - | 477 | WP_001186747.1 | RadC family protein | - |
| MYG04_RS10855 (2234128) | 2234128..2234613 | - | 486 | WP_000214317.1 | antirestriction protein | - |
| MYG04_RS10860 (2234704) | 2234704..2235522 | - | 819 | WP_001234702.1 | DUF932 domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 128 a.a. Molecular weight: 14295.32 Da Isoelectric Point: 8.2830
>T242643 WP_000854822.1 NZ_CP095856:c2232809-2232426 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHQESKRCN
Download Length: 384 bp
>T242643 NZ_OW849082:c2048610-2048116 [Citrobacter freundii]
ATGGAATACTTAGAAATAAATGGTTGGAAAATCTGCTTTCACAAATGCTTTTTGGATCAGATTACAGAACTCGCGAAGAA
GGTAGCTGAATTAAAAGCGGCGAAACCTAGCGAATACCACACCAAAAAAGAAACAAAACTCCTTCGTGCGATTGAGCGTG
TTATTGAGGAATGGATTGCTTCAGATCCACTCAATCCGCAGTATCGTCAGGGAGAAACTTTAGGCGACGAGTACAAACAC
TGGTTCCGCGTAAAGTTTTTACAACAGTTCCGTTTGTTTTTTCGTTGTAGCCAGGAGCACAAAACTATCATCATTGGTTG
GGTAAATGATTTTGGTACGCTTCGGGCATACGGTTCGAAAACGGATGCTTATAAAGTGTTTGCTGCCATGTTGGACGCAG
GTAATCCACCGGATGACTGGGACAAACTTCTCAACGCGGCAACGAAAGCCACGGCTACAGCCAGTATTCCAGATTTTCTC
ACCAGGCAACCCTGA
ATGGAATACTTAGAAATAAATGGTTGGAAAATCTGCTTTCACAAATGCTTTTTGGATCAGATTACAGAACTCGCGAAGAA
GGTAGCTGAATTAAAAGCGGCGAAACCTAGCGAATACCACACCAAAAAAGAAACAAAACTCCTTCGTGCGATTGAGCGTG
TTATTGAGGAATGGATTGCTTCAGATCCACTCAATCCGCAGTATCGTCAGGGAGAAACTTTAGGCGACGAGTACAAACAC
TGGTTCCGCGTAAAGTTTTTACAACAGTTCCGTTTGTTTTTTCGTTGTAGCCAGGAGCACAAAACTATCATCATTGGTTG
GGTAAATGATTTTGGTACGCTTCGGGCATACGGTTCGAAAACGGATGCTTATAAAGTGTTTGCTGCCATGTTGGACGCAG
GTAATCCACCGGATGACTGGGACAAACTTCTCAACGCGGCAACGAAAGCCACGGCTACAGCCAGTATTCCAGATTTTCTC
ACCAGGCAACCCTGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13679.41 Da Isoelectric Point: 6.4758
>AT242643 WP_053271974.1 NZ_CP095856:c2233267-2232899 [Escherichia coli]
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN
VSDTFSGTTHPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLTDRAGIRGRFSDADANHLDQAFPLLMKQLELMLTSS
ELNPHRQNTVTLYVKGLTCHADTLGSCGYVYLAVYPTPEMKN
Download Length: 369 bp
>AT242643 NZ_OW849082:c2048979-2048635 [Citrobacter freundii]
ATGGCTACTCAAATTTTAAATAGTGCGGACGTGTCACTGCGCGCTGAGTCCCGACTCACTGAACGCAGCCAGACTACGAT
TCCAGCAGCAATACGCGATGCTTTGCATCTCAAGCCAGGTGAGTCCATTCACTATACCTTGCTTGCGGGTGGTAAAGTTA
TCATGTCACGAAAGGATGAAGAACAGGACGACCCGGTTGTATCACAGTTTCTGGCTTTTCTTGAAAAAGACATGAAGAAA
AACCCACAGAATATTGCCCCTGTTCCGGCATTTTTCTGGGAAAGCATCAAATCATTAACTGCTGGAGTTGAGGTTGATTT
AGACGCGCCGCTTACCGATAGTTAA
ATGGCTACTCAAATTTTAAATAGTGCGGACGTGTCACTGCGCGCTGAGTCCCGACTCACTGAACGCAGCCAGACTACGAT
TCCAGCAGCAATACGCGATGCTTTGCATCTCAAGCCAGGTGAGTCCATTCACTATACCTTGCTTGCGGGTGGTAAAGTTA
TCATGTCACGAAAGGATGAAGAACAGGACGACCCGGTTGTATCACAGTTTCTGGCTTTTCTTGAAAAAGACATGAAGAAA
AACCCACAGAATATTGCCCCTGTTCCGGCATTTTTCTGGGAAAGCATCAAATCATTAACTGCTGGAGTTGAGGTTGATTT
AGACGCGCCGCTTACCGATAGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M0WJM1 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A1M0CWL2 |