Detailed information of TA system TA242520

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/-
• Location: 4195707..4196928
• Replicon: chromosome
• Accession: NZ_CP095770
• Organism: Pseudomonas aeruginosa strain 34Pae36

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A0H2Z8V4
• Locus tag: MX654_RS20020
• Protein ID: WP_003110488.1
• Coordinates: 4196350..4196928 (+)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: MX654_RS20015
• Protein ID: WP_003088112.1
• Coordinates: 4195707..4196261 (+)
• Length: 185 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MX654_RS19990	4191275..4191826	+	552	WP_003450159.1	XRE family transcriptional regulator	-
MX654_RS19995	4191823..4192221	-	399	WP_003088123.1	NADH-quinone oxidoreductase subunit A	-
MX654_RS20000	4192234..4192557	-	324	WP_015648646.1	multidrug efflux SMR transporter	-
MX654_RS20005	4192888..4193349	+	462	WP_003102736.1	(2Fe-2S)-binding protein	-
MX654_RS20010	4193354..4195549	+	2196	WP_003122807.1	xanthine dehydrogenase family protein molybdopterin-binding subunit	-
MX654_RS20015	4195707..4196261	+	555	WP_003088112.1	helix-turn-helix transcriptional regulator	Antitoxin
MX654_RS20020	4196350..4196928	+	579	WP_003110488.1	HD domain-containing protein	Toxin
MX654_RS20025	4197037..4198224	-	1188	WP_003102741.1	HlyD family efflux transporter periplasmic adaptor subunit	-
MX654_RS20030	4198214..4200385	-	2172	WP_025297367.1	type I secretion system permease/ATPase	-
MX654_RS20035	4200375..4201652	-	1278	WP_003102743.1	TolC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• 5'-deoxynucleotidase YfbR/HDDC2 (7-188)

Antitoxin

• Cro/C1-type helix-turn-helix domain (14-62)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21913.75 Da
• Isoelectric Point: 5.3655

>T242520 WP_003110488.1 NZ_CP095770:4196350-4196928 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDTPLRDRLLALWDEYERGETAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Nucleotide

• Length: 579 bp

>T242520 NZ_OW706512:4038881-4039168 [Salmonella enterica subsp. enterica serovar Typhi]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGCTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCTCGTAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin

Protein

• Length: 185 a.a.
• Molecular weight: 20454.63 Da
• Isoelectric Point: 8.1590

>AT242520 WP_003088112.1 NZ_CP095770:4195707-4196261 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Nucleotide

• Length: 555 bp

>AT242520 NZ_OW706512:4039155-4039457 [Salmonella enterica subsp. enterica serovar Typhi]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGACAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGACGTTATGGAATGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTGAATGCCATTCTGCGCGAAGCGATGCTGCGCGAGCAAAATAAGAAATAG

Structures

Toxin

• AlphaFold DB: A0A0H2Z8V4