Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4774077..4774593 Replicon chromosome
Accession NZ_CP095557
Organism Klebsiella pneumoniae strain BA11088

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag MXX37_RS23320 Protein ID WP_040216106.1
Coordinates 4774077..4774361 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag MXX37_RS23325 Protein ID WP_064162488.1
Coordinates 4774351..4774593 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MXX37_RS23295 (4769494) 4769494..4769757 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
MXX37_RS23300 (4769887) 4769887..4770060 + 174 WP_032425422.1 hypothetical protein -
MXX37_RS23305 (4770063) 4770063..4770806 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
MXX37_RS23310 (4771163) 4771163..4773301 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
MXX37_RS23315 (4773609) 4773609..4774073 + 465 WP_064162487.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MXX37_RS23320 (4774077) 4774077..4774361 - 285 WP_040216106.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MXX37_RS23325 (4774351) 4774351..4774593 - 243 WP_064162488.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MXX37_RS23330 (4774671) 4774671..4776581 - 1911 WP_023325426.1 PRD domain-containing protein -
MXX37_RS23335 (4776604) 4776604..4777758 - 1155 WP_064162489.1 lactonase family protein -
MXX37_RS23340 (4777825) 4777825..4778565 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11097.94 Da        Isoelectric Point: 10.4962

>T242423 WP_040216106.1 NZ_CP095557:c4774361-4774077 [Klebsiella pneumoniae]
MTYELAFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T242423 NZ_OW052571:c3994696-3994394 [Mycobacterium tuberculosis]
TTGATCGCTCCCGGCGACATCGCGCCGCGCCGCGACAGTGAACACGAGCTCTACGTCGCCGTCTTGTCCAACGCGCTCCA
TCGGGCCGCGGACACCGGACGGGTGATCACCTGCCCATTCATTCCGGGCCGGGTCCCCGAGGATCTCTTGGCGATGGTGG
TGGCGGTCGAGCAACCCAACGGCACGCTGCTGCCGGAACTCGTGCAGTGGCTTCATGTTGCCGCGCTCGGTGCGCCACTC
GGCAACGCGGGCGTGGCCGCCCTACGCGAGGCTGCCTCGGTCGTGACAGCTCTGCTCTGTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9059.57 Da        Isoelectric Point: 6.3340

>AT242423 WP_064162488.1 NZ_CP095557:c4774593-4774351 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPLKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT242423 NZ_OW052571:c3994346-3994125 [Mycobacterium tuberculosis]
ATGAGTGATGTACTGATTCGGGACATCCCCGACGACGTGTTAGCAAGCCTTGACGCGATCGCGGCACGCTTGGGCTTGTC
GCGGACCGAATACATCCGTCGGCGTTTAGCCCAGGATGCGCAGACGGCTCGCGTCACCGTGACAGCCGCGGATCTTCGAC
GCCTCAGGGGTGCGGTTGCCGGTCTGGGCGATCCCGAGCTTATGCGTCAGGCGTGGAGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References