Detailed information of TA system TA024208

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): ldrD-ohsC/Ldr(toxin)
• Location: 4501272..4501493
• Replicon: chromosome
• Accession: NC_013008
• Organism: Escherichia coli O157:H7 str. TW14359

Toxin (Protein)

• Gene name: ldrD
• Uniprot ID: S1NWX0
• Locus tag: ECSP_RS32515
• Protein ID: WP_001295224.1
• Coordinates: 4501272..4501379 (-)
• Length: 36 a.a.

Antitoxin (RNA)

Gene name	ohsC
Locus tag	-
Coordinates	4501428..4501493 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ECSP_RS23500	4496525..4497277	-	753	Protein_4440	cellulose biosynthesis protein BcsQ	-
ECSP_RS23510	4497289..4497477	-	189	WP_001063316.1	YhjR family protein	-
ECSP_RS23515	4497750..4499321	+	1572	WP_001204920.1	cellulose biosynthesis protein BcsE	-
ECSP_RS23520	4499318..4499509	+	192	WP_000988308.1	cellulose biosynthesis protein BcsF	-
ECSP_RS23525	4499506..4501185	+	1680	WP_000191596.1	cellulose biosynthesis protein BcsG	-
ECSP_RS32515	4501272..4501379	-	108	WP_001295224.1	type I toxin-antitoxin system toxin Ldr family protein	Toxin
-	4501428..4501493	+	66	NuclAT_16	-	Antitoxin
-	4501428..4501493	+	66	NuclAT_16	-	Antitoxin
-	4501428..4501493	+	66	NuclAT_16	-	Antitoxin
-	4501428..4501493	+	66	NuclAT_16	-	Antitoxin
-	4501428..4501493	+	66	NuclAT_21	-	Antitoxin
-	4501428..4501493	+	66	NuclAT_21	-	Antitoxin
-	4501428..4501493	+	66	NuclAT_21	-	Antitoxin
-	4501428..4501493	+	66	NuclAT_21	-	Antitoxin
ECSP_RS23540	4501855..4503126	+	1272	WP_001301684.1	amino acid permease	-
ECSP_RS23545	4503156..4504160	-	1005	WP_000107027.1	dipeptide ABC transporter ATP-binding subunit DppF	-
ECSP_RS23550	4504157..4505140	-	984	WP_001196486.1	dipeptide ABC transporter ATP-binding protein	-
ECSP_RS23555	4505151..4506053	-	903	WP_000084677.1	dipeptide ABC transporter permease DppC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Type I toxin-antitoxin system, toxin Ldr (1-35)

Sequences

Toxin

Protein

• Length: 36 a.a.
• Molecular weight: 3882.70 Da
• Isoelectric Point: 9.0157

>T24208 WP_001295224.1 NC_013008:c4501379-4501272 [Escherichia coli O157:H7 str. TW14359]
MTLAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Nucleotide

• Length: 108 bp

>T24208 NC_013008:c4501379-4501272 [Escherichia coli O157:H7 str. TW14359]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 66 bp

>AT24208 NC_013008:4501428-4501493 [Escherichia coli O157:H7 str. TW14359]
GTCTAGGTTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Toxin

• AlphaFold DB: A0A4P7TSJ7

Antitoxin