Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2799855..2801443 Replicon chromosome
Accession NZ_CP095426
Organism Klebsiella pneumoniae strain IM029

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag MWR69_RS13965 Protein ID WP_004199851.1
Coordinates 2799855..2801177 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag MWR69_RS13970 Protein ID WP_002904790.1
Coordinates 2801177..2801443 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MWR69_RS13950 (MWR69_13935) 2794920..2797421 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
MWR69_RS13955 (MWR69_13940) 2797409..2798413 + 1005 WP_004199852.1 fimbrial protein -
MWR69_RS13960 (MWR69_13945) 2798546..2799838 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
MWR69_RS13965 (MWR69_13950) 2799855..2801177 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
MWR69_RS13970 (MWR69_13955) 2801177..2801443 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
MWR69_RS13975 (MWR69_13960) 2801709..2802035 - 327 WP_002904788.1 hydroxyisourate hydrolase -
MWR69_RS13980 (MWR69_13965) 2802032..2802532 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
MWR69_RS13985 (MWR69_13970) 2802510..2803889 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
MWR69_RS13990 (MWR69_13975) 2804235..2805389 + 1155 Protein_2742 FAD-dependent urate hydroxylase HpxO -
MWR69_RS13995 (MWR69_13980) 2805370..2806293 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T241961 WP_004199851.1 NZ_CP095426:c2801177-2799855 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

>T241961 NZ_OU701452:c4075118-4075011 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGCATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT241961 WP_002904790.1 NZ_CP095426:c2801443-2801177 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp

>AT241961 NZ_OU701452:4075176-4075230 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References