Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 3454768..3455420 Replicon chromosome
Accession NZ_CP095280
Organism Aeromonas hydrophila strain Ah2111

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag MUW98_RS15870 Protein ID WP_128313514.1
Coordinates 3454768..3455118 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MUW98_RS15875 Protein ID WP_128313513.1
Coordinates 3455118..3455420 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW98_RS15855 (MUW98_15855) 3450806..3451054 - 249 WP_281440938.1 AlpA family phage regulatory protein -
MUW98_RS15860 (MUW98_15860) 3451156..3453237 + 2082 WP_247141913.1 hypothetical protein -
MUW98_RS15865 (MUW98_15865) 3453770..3454720 + 951 WP_247141910.1 DUF932 domain-containing protein -
MUW98_RS15870 (MUW98_15870) 3454768..3455118 + 351 WP_128313514.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MUW98_RS15875 (MUW98_15875) 3455118..3455420 + 303 WP_128313513.1 XRE family transcriptional regulator Antitoxin
MUW98_RS15880 (MUW98_15880) 3455596..3456600 + 1005 WP_247146301.1 YqaJ viral recombinase family protein -
MUW98_RS15885 (MUW98_15885) 3456597..3457535 + 939 WP_247141906.1 hypothetical protein -
MUW98_RS15890 (MUW98_15890) 3457537..3457884 - 348 WP_029303609.1 helix-turn-helix transcriptional regulator -
MUW98_RS15895 (MUW98_15895) 3458367..3458558 + 192 WP_200164040.1 hypothetical protein -
MUW98_RS15900 (MUW98_15900) 3458655..3459287 + 633 WP_247146302.1 hypothetical protein -
MUW98_RS15905 (MUW98_15905) 3459372..3459932 + 561 WP_247146303.1 lecithin retinol acyltransferase family protein -
MUW98_RS15910 (MUW98_15910) 3459970..3460395 + 426 WP_247146304.1 DUF2787 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3446659..3490044 43385


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-106)

Antitoxin

HigA2-like, helix-turn-helix domain

(5-89)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13090.03 Da        Isoelectric Point: 6.4693

>T241893 WP_128313514.1 NZ_CP095280:3454768-3455118 [Aeromonas hydrophila]
MWTVKTTELFDVWFDVQDDATQEKVLAGLLALAQGGPSIGRPLVDTIKGSRFTNLKELRVQHQGEPLRAFFAFDPLRQAI
VLCAGNKGGNEKRFYKEMLPLAEAQYARHLAELEEK

Download         Length: 351 bp

>T241893 NZ_OU659150:4007010-4007264 [Providencia alcalifaciens]
ATGAAAACCATTTCCTTTAGTGATGCTAGAAGCAATTTGAAAGCAGTGCTTGATAGAGTTGTTGATGATATGGATACGAC
GATTATAACCCGCCGTGATTCTGAAGCGGCTGTAGTTATGTCCTTGGAATACTACAATAGTTTAATGGAAACCATCTATC
TACTGCGCTCTCCTGCAAATGCAGAGCATCTCAACAAATCCATCGAGCAATTTAAAGCGGGTAAGATTTCAGAGAGAAAG
CTAATCAATGAGTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11192.90 Da        Isoelectric Point: 5.2187

>AT241893 WP_128313513.1 NZ_CP095280:3455118-3455420 [Aeromonas hydrophila]
MGRTLDDLLASRSEESRQRIQEMANELLLEVRIQALREELEVSQVELAKALGVSQPAVVAMEQRGSDIKLSTMKRYVEAM
GGKLRVDVELPTGRHIGFNV

Download         Length: 303 bp

>AT241893 NZ_OU659150:4007257-4007517 [Providencia alcalifaciens]
ATGAGTAGACTTCTAACATGGACGGATCAAGCTTGGGAAGACTATCTATACTGGCAAAACCAAGATAAAAAGACATTAAA
GCGGATAAATAAACTCATTGAAGACACGAAAAGAACGCCATTCAGCGGTATAGGTAAACCAGAGCCACTAAAAGAAAACT
TGGCTGGCTTCTGGTCTCGTAGAATAGATGAAACAAACAGGCTAGTTTATGCAATCGAAAATACCGCATTAGTTATCATT
GCCTGCCGCTATCACTACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References