Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1871877..1872712 Replicon chromosome
Accession NZ_CP095155
Organism Escherichia coli strain Iso00041

Toxin (Protein)


Gene name yeeV Uniprot ID A0A1X9TM58
Locus tag MU410_RS09005 Protein ID WP_000854761.1
Coordinates 1871877..1872254 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID S1NM52
Locus tag MU410_RS09010 Protein ID WP_001295723.1
Coordinates 1872344..1872712 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU410_RS08965 (1867266) 1867266..1867631 - 366 WP_001282181.1 EutP/PduV family microcompartment system protein -
MU410_RS08970 (1867902) 1867902..1868291 - 390 WP_174490791.1 transposase -
MU410_RS08975 (1868480) 1868480..1868704 - 225 Protein_1760 transposase -
MU410_RS08980 (1868785) 1868785..1869189 + 405 WP_000839179.1 transposase -
MU410_RS08985 (1869186) 1869186..1869533 + 348 WP_000612626.1 IS66 family insertion sequence element accessory protein TnpB -
MU410_RS08990 (1869582) 1869582..1871121 + 1540 Protein_1763 IS66-like element ISEc22 family transposase -
MU410_RS08995 (1871552) 1871552..1871632 - 81 Protein_1764 hypothetical protein -
MU410_RS09000 (1871732) 1871732..1871880 - 149 Protein_1765 DUF5983 family protein -
MU410_RS09005 (1871877) 1871877..1872254 - 378 WP_000854761.1 TA system toxin CbtA family protein Toxin
MU410_RS09010 (1872344) 1872344..1872712 - 369 WP_001295723.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MU410_RS09015 (1872875) 1872875..1873096 - 222 WP_000692345.1 DUF987 domain-containing protein -
MU410_RS09020 (1873159) 1873159..1873635 - 477 WP_001186775.1 RadC family protein -
MU410_RS09025 (1873651) 1873651..1874124 - 474 WP_000855059.1 antirestriction protein -
MU410_RS09030 (1874466) 1874466..1875284 - 819 WP_001765427.1 DUF932 domain-containing protein -
MU410_RS09035 (1875439) 1875439..1875597 - 159 WP_001323397.1 DUF905 family protein -
MU410_RS09040 (1875743) 1875743..1876489 - 747 WP_001016257.1 IS21-like element ISEc12 family helper ATPase IstB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1868785..1878045 9260


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14205.25 Da        Isoelectric Point: 7.3249

>T241568 WP_000854761.1 NZ_CP095155:c1872254-1871877 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTHSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPEAKR

Download         Length: 378 bp

>T241568 NZ_LT992489:c384046-383777 [Vibrio cholerae]
ATGCCAGAGATTGATGCCCTATTAGGTCTTTCATTTTGCTTGTACTTCTTTGATAACAAGCAGCATAAATTACCTCATAT
TCACGTTAAGTACGGTAGTTACGAGCTAATTATTGCTATTGAAACAGGTGAGTGTTTAGAGGGTTACTTACCCAATAAGC
AACGAAAACGTGCTGAAAACCATATTCTTGAACATCGAGAGCAATTGATGGTGATGTGGAATAAAGCGGTGAATGGTGAA
AATCCAGGTAAGTTAGGTGATTTATGTTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13592.40 Da        Isoelectric Point: 6.6255

>AT241568 WP_001295723.1 NZ_CP095155:c1872712-1872344 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT241568 NZ_LT992489:c383783-383262 [Vibrio cholerae]
ATGTTGAAAGTCATAGATGTTGATTTTGTCTCAGACCATACATTAGAACTGACGTTCAATGATGGTTACCAAGGCTATGC
CGACTTGTCGGTATACTTTAAAAAAGCACCGTTTTCAGAAATTAAGGACTTTAAACGCTTTTCCTTGACTCGTGATGGCT
CGTTAAATTGGGATGGTAATGAGTTAACGGCCGCGACACTCCGTGACATAACCAAGGGCTCACAAAAGTCGGTGGAGTTA
AGTTTTAATGTTCAAGAAATGGAAGCCGTCATCAAACAGGCCTCATGGGAATCGATGATGGAGGGGCGTCCCGACATCTT
GCAAGCGGCTATTCGTTCTTACGTAGAGCAGTTTGGTCATGGTCAAGTTATTGCAAAGGCGGGTATAAAAAGTCGTACGA
GTGCTTATCGCTCCTTGAAGCCAGAAACAACGCCAAACTTTGGCACACTAGTTCAGTTAGGGCACGCCGTCATCGAACTA
GCGAAAGATAGAACAGTGGCAAACAAGGAACCACGCATATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X9TM58

Antitoxin

Source ID Structure
AlphaFold DB S1NM52

References