Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 51293..52128 Replicon chromosome
Accession NZ_CP095155
Organism Escherichia coli strain Iso00041

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag MU410_RS00265 Protein ID WP_001565141.1
Coordinates 51293..51670 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag MU410_RS00270 Protein ID WP_001565140.1
Coordinates 51760..52128 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU410_RS00235 (46661) 46661..47581 - 921 WP_245075077.1 carboxylate/amino acid/amine transporter -
MU410_RS00240 (47692) 47692..48876 - 1185 WP_001172898.1 sugar efflux transporter -
MU410_RS00245 (49273) 49273..49434 - 162 Protein_48 RhuM family protein -
MU410_RS00250 (49672) 49672..50514 - 843 WP_001565143.1 DUF4942 domain-containing protein -
MU410_RS00255 (50599) 50599..50796 - 198 WP_000839256.1 DUF957 domain-containing protein -
MU410_RS00260 (50808) 50808..51296 - 489 WP_001565142.1 DUF5983 family protein -
MU410_RS00265 (51293) 51293..51670 - 378 WP_001565141.1 TA system toxin CbtA family protein Toxin
MU410_RS00270 (51760) 51760..52128 - 369 WP_001565140.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MU410_RS00275 (52203) 52203..52424 - 222 WP_000692303.1 DUF987 domain-containing protein -
MU410_RS00280 (52493) 52493..52969 - 477 WP_001186771.1 RadC family protein -
MU410_RS00285 (52985) 52985..53470 - 486 WP_001737493.1 antirestriction protein -
MU410_RS00290 (53562) 53562..54380 - 819 WP_001234749.1 DUF932 domain-containing protein -
MU410_RS00295 (54471) 54471..54704 - 234 WP_001117560.1 DUF905 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14246.27 Da        Isoelectric Point: 7.2920

>T241561 WP_001565141.1 NZ_CP095155:c51670-51293 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SICPRSQLINSIDILRARRATGLMTRDNYRMVNNITQGKHPEAQQ

Download         Length: 378 bp

>T241561 NZ_LT992487:c964882-964616 [Vibrio cholerae]
ATGATTAAATTTGAATTTGATGAAAACAAAAGCAGAAGTAATCTCGAAAAGCACGGTATTGATTTTCATACAGCTCAAGG
ATTGTGGAATGATTCAGATCTTATCGAGATCCCTGCTAACACGAGTGATGAGCCCAGATATTTGGTTGTCGGCTTACTAA
ACGGTAAGCATTGGTCAGGAGTAATTACCTACCGAGGTACGAATATCAGGATCATCTCAGTTCGGCGTTCACGGAAAGCG
GAGGTAAGCCTTTATGAAAGCGCATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13604.41 Da        Isoelectric Point: 6.7389

>AT241561 WP_001565140.1 NZ_CP095155:c52128-51760 [Escherichia coli]
VSDTLPGTTHPDDNHDRLWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFALLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK

Download         Length: 369 bp

>AT241561 NZ_LT992487:c964629-964384 [Vibrio cholerae]
ATGAAAGCGCATGAATTTGATGCCAAGTTTGAAAGTGACGACGATGATATCGTAATGGACTTGGATCTATCGCAAGCTAA
AAGACCGATGCATAAGCAAAAACGAGTCAATGTAGATTTTCCAGCCTGGATGCTTGAGTCCTTGGACAGAGAAGCGAGTC
GTATTGGTGTAACACGTCAATCAATCATTAAAATTTGGCTGGCAGAAAGGTTAGAGAGCGTGTCTCATCATTCAAGTGTG
AGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References