Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4119614..4120233 Replicon chromosome
Accession NZ_CP095140
Organism Klebsiella pneumoniae strain Iso00199

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MU413_RS20550 Protein ID WP_002892050.1
Coordinates 4120015..4120233 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MU413_RS20545 Protein ID WP_002892066.1
Coordinates 4119614..4119988 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MU413_RS20535 (4114766) 4114766..4115959 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MU413_RS20540 (4115982) 4115982..4119128 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
MU413_RS20545 (4119614) 4119614..4119988 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MU413_RS20550 (4120015) 4120015..4120233 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MU413_RS20555 (4120393) 4120393..4120959 + 567 WP_002892030.1 maltose O-acetyltransferase -
MU413_RS20560 (4120931) 4120931..4121071 - 141 WP_004147370.1 hypothetical protein -
MU413_RS20565 (4121092) 4121092..4121562 + 471 WP_002892026.1 YlaC family protein -
MU413_RS20570 (4121537) 4121537..4122988 - 1452 WP_023302231.1 PLP-dependent aminotransferase family protein -
MU413_RS20575 (4123089) 4123089..4123787 + 699 WP_002892021.1 GNAT family protein -
MU413_RS20580 (4123784) 4123784..4123924 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MU413_RS20585 (4123924) 4123924..4124187 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T241509 WP_002892050.1 NZ_CP095140:4120015-4120233 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T241509 NZ_LT992474:c1499057-1498869 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT241509 WP_002892066.1 NZ_CP095140:4119614-4119988 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT241509 NZ_LT992474:c1499345-1499085 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References