Detailed information of TA system TA241225

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 4391512..4391770
• Replicon: chromosome
• Accession: NZ_CP095083
• Organism: Escherichia coli strain EC6868

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: MUK76_RS21475
• Protein ID: WP_000809168.1
• Coordinates: 4391618..4391770 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	4391512..4391569 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUK76_RS21460	4387904..4388863	+	960	WP_000871674.1	hypothetical protein	-
MUK76_RS21465	4388901..4389800	-	900	WP_001300855.1	transcriptional activator NhaR	-
MUK76_RS21470	4389866..4391032	-	1167	WP_000681360.1	Na+/H+ antiporter NhaA	-
-	4391512..4391569	-	58	-	-	Antitoxin
MUK76_RS21475	4391618..4391770	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
MUK76_RS21480	4391874..4393004	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
MUK76_RS21485	4393093..4395009	-	1917	WP_000516135.1	molecular chaperone DnaK	-
MUK76_RS21490	4395385..4395789	+	405	WP_000843584.1	DUF2541 family protein	-
MUK76_RS21495	4395815..4396528	+	714	WP_001102367.1	acidic protein MsyB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T241225 WP_000809168.1 NZ_CP095083:4391618-4391770 [Escherichia coli]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T241225 NZ_LT963396:126290-126667 [Pseudomonas cerasi]
ATGACAAACAAAGAAAAACCGCTCGAATGGATCGCGAGCAGCCACAAGGATTTGATGGCGTTGCCGTCCGACGTGCGTCG
CCGTTTCGGTTACGCGCTCTCGTTGGCGCAGATAGGCGATCAGGATGACGCAGCAAAGGTGCTCAAGGGGTTCGGTGGTG
CCGGCGTGCTGGAGGTCGTCGAAGACGATGCCGGCGGCACCTATCGAGCGGTATACACGGTCAAGTTTGCGGAAGCGGTG
TTCGTCCTGCACTGCTTCCAGAAGAAGAGCAAGAGCGGAATCGCCACGCCAAAGGCCGACATGGACATCATCCGCGCTCG
GCTGAAGGTGGCCGAGGTATTGGCACAGGAGCTACGAAATGCAAAAACGAATCATTGA

Antitoxin

Nucleotide

• Length: 58 bp

>AT241225 NZ_CP095083:c4391569-4391512 [Escherichia coli]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin