Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 442562..443573 Replicon chromosome
Accession NZ_CP095020
Organism Mycobacterium tuberculosis strain SGF0232017

Toxin (Protein)


Gene name pezT Uniprot ID L7N5R2
Locus tag MUW65_RS01920 Protein ID WP_003401859.1
Coordinates 442562..443155 (-) Length 198 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID O53702
Locus tag MUW65_RS01925 Protein ID WP_003401860.1
Coordinates 443184..443573 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MUW65_RS01900 (MUW65_01900) 438211..439593 + 1383 WP_003898415.1 magnesium transporter -
MUW65_RS01905 (MUW65_01905) 439605..440639 - 1035 WP_003401856.1 class II fructose-bisphosphate aldolase -
MUW65_RS01910 (MUW65_01910) 440735..441418 + 684 WP_003401857.1 VTT domain-containing protein -
MUW65_RS01915 (MUW65_01915) 441407..442537 - 1131 WP_003401858.1 glycoside hydrolase family 76 protein -
MUW65_RS01920 (MUW65_01920) 442562..443155 - 594 WP_003401859.1 zeta toxin family protein Toxin
MUW65_RS01925 (MUW65_01925) 443184..443573 - 390 WP_003401860.1 hypothetical protein Antitoxin
MUW65_RS01930 (MUW65_01930) 443654..444865 - 1212 WP_003401861.1 VWA domain-containing protein -
MUW65_RS01935 (MUW65_01935) 444871..445473 - 603 WP_003898417.1 SRPBCC family protein -
MUW65_RS01940 (MUW65_01940) 445487..446383 - 897 WP_003898418.1 MoxR family ATPase -
MUW65_RS01945 (MUW65_01945) 446380..446973 - 594 WP_003401864.1 NTP transferase domain-containing protein -
MUW65_RS01950 (MUW65_01950) 446970..447725 - 756 WP_003401865.1 XdhC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-156)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 198 a.a.        Molecular weight: 21344.53 Da        Isoelectric Point: 10.5018

>T240954 WP_003401859.1 NZ_CP095020:c443155-442562 [Mycobacterium tuberculosis]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEGLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRIVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Download         Length: 594 bp

>T240954 NZ_LT897798:438398-438685 [Vibrio cholerae]
ATGGCATTAGAATTTAAAGATAAGTGGTTAGAGCAGTTTTACGAGGATGATAAACGACATCGTTTAATTCCAAGTAGCAT
AGAGAATGCTCTATTTCGGAAGCTGGAAATCTTAGATGCAGCCCAAGCTGAATCTGACTTAAGAATTCCACCGGGTAATC
GTTTTGAACATCTTGAAGGAAATCTTAAAGGTTGGTGTTCAATTCGAGTGAACAAACAGTATCGTTTGATTTTTCAGTGG
GTTGATGGTGTTGCACTAAATACTTACTTAGACCCACATAAGTATTGA

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13648.21 Da        Isoelectric Point: 6.0829

>AT240954 WP_003401860.1 NZ_CP095020:c443573-443184 [Mycobacterium tuberculosis]
VPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMTDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Download         Length: 390 bp

>AT240954 NZ_LT897798:438696-439013 [Vibrio cholerae]
ATGCGTAAGACAAAACGTCGTCCAGTTAGCGTTGGGGAAATGTTAAAAGTTGAATTTCTTGAACCAATGGGCATCACATC
AAAAGCGCTCGCTGAAGCGATGGGCGTACACAGAAATACGGTGAGTAATTTGATTAATGGCGGTGTGTTAACAGCTCCGG
TAGCAATCAAGTTAGCAGCGGCACTAGGTAATACACCAGAGTTTTGGCTTAATATTCAACATGCAGTTGATCTTTGGGAC
ACGAGAAATCGTTATCAAGAAGAAGCAAAATTTGTAAAGCCGTTGTTTGTTTCGCTGGAACAAAGCGCACGTACATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U4BRU8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BRT0

References