Detailed information of TA system TA240684

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 2217663..2218168
• Replicon: chromosome
• Accession: NZ_CP094855
• Organism: Staphylococcus aureus strain NY2491

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MTX64_RS11240
• Protein ID: WP_001103948.1
• Coordinates: 2217663..2217956 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IY59
• Locus tag: MTX64_RS11245
• Protein ID: WP_001058494.1
• Coordinates: 2217959..2218168 (-)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MTX64_RS11210 (2212853)	2212853..2213194	-	342	WP_001190605.1	hypothetical protein	-
MTX64_RS11215 (2213644)	2213644..2214285	-	642	WP_001019784.1	hypothetical protein	-
MTX64_RS11220 (2214282)	2214282..2214566	-	285	WP_000998180.1	hypothetical protein	-
MTX64_RS11225 (2214568)	2214568..2214930	-	363	WP_001039167.1	hypothetical protein	-
MTX64_RS11230 (2215232)	2215232..2216689	-	1458	WP_000432707.1	virulence-associated E family protein	-
MTX64_RS11235 (2216706)	2216706..2217575	-	870	WP_001002692.1	primase alpha helix C-terminal domain-containing protein	-
MTX64_RS11240 (2217663)	2217663..2217956	-	294	WP_001103948.1	DUF1474 family protein	Toxin
MTX64_RS11245 (2217959)	2217959..2218168	-	210	WP_001058494.1	hypothetical protein	Antitoxin
MTX64_RS11250 (2218161)	2218161..2218307	-	147	WP_000784885.1	hypothetical protein	-
MTX64_RS11255 (2218304)	2218304..2218621	-	318	WP_000481967.1	helix-turn-helix domain-containing protein	-
MTX64_RS11260 (2218626)	2218626..2218844	-	219	WP_000153640.1	helix-turn-helix transcriptional regulator	-
MTX64_RS11265 (2219017)	2219017..2219691	+	675	WP_000620857.1	helix-turn-helix transcriptional regulator	-
MTX64_RS11270 (2219705)	2219705..2220877	+	1173	WP_000179344.1	tyrosine-type recombinase/integrase	-
MTX64_RS11275 (2220946)	2220946..2222562	-	1617	WP_000240653.1	chaperonin GroEL	-
MTX64_RS11280 (2222638)	2222638..2222922	-	285	WP_000917289.1	co-chaperone GroES	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-97)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11576.05 Da
• Isoelectric Point: 4.9594

>T240684 WP_001103948.1 NZ_CP094855:c2217956-2217663 [Staphylococcus aureus]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSGSYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASLQADQSESNA

Nucleotide

• Length: 294 bp

>T240684 NZ_LT615377:c246407-246129 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8268.31 Da
• Isoelectric Point: 4.3718

>AT240684 WP_001058494.1 NZ_CP094855:c2218168-2217959 [Staphylococcus aureus]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNSIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240684 NZ_LT615377:c246670-246410 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Structures

Antitoxin

• AlphaFold DB: X5IY59