Detailed information of TA system TA240177

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 875363..875901
• Replicon: chromosome
• Accession: NZ_CP094752
• Organism: Staphylococcus aureus strain IVB6243

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: -
• Locus tag: MUA86_RS04240
• Protein ID: WP_262516296.1
• Coordinates: 875575..875901 (+)
• Length: 109 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: -
• Locus tag: MUA86_RS04235
• Protein ID: WP_250406114.1
• Coordinates: 875363..875572 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA86_RS04200 (871226)	871226..872446	-	1221	WP_262515151.1	site-specific integrase	-
MUA86_RS04205 (872657)	872657..873337	-	681	WP_262516294.1	type II toxin-antitoxin system PemK/MazF family toxin	-
MUA86_RS04210 (873477)	873477..873644	-	168	WP_031806878.1	hypothetical protein	-
MUA86_RS04215 (873841)	873841..874479	-	639	WP_250406350.1	XRE family transcriptional regulator	-
MUA86_RS04220 (874670)	874670..874924	+	255	WP_250425964.1	helix-turn-helix transcriptional regulator	-
MUA86_RS04225 (874940)	874940..875212	+	273	WP_250425965.1	helix-turn-helix domain-containing protein	-
MUA86_RS04230 (875224)	875224..875370	+	147	WP_250406348.1	pathogenicity island protein	-
MUA86_RS04235 (875363)	875363..875572	+	210	WP_250406114.1	pathogenicity island protein	Antitoxin
MUA86_RS04240 (875575)	875575..875901	+	327	WP_262516296.1	DUF1474 family protein	Toxin
MUA86_RS04245 (875966)	875966..876835	+	870	WP_262516297.1	primase alpha helix C-terminal domain-containing protein	-
MUA86_RS04250 (876852)	876852..878321	+	1470	WP_262516298.1	virulence-associated E family protein	-
MUA86_RS04255 (878601)	878601..878963	+	363	WP_045178622.1	hypothetical protein	-
MUA86_RS04260 (878965)	878965..879228	+	264	WP_001804819.1	hypothetical protein	-
MUA86_RS04265 (879230)	879230..879871	+	642	WP_252580283.1	pathogenicity island protein	-
MUA86_RS04270 (880218)	880218..880559	+	342	WP_262516299.1	pathogenicity island protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	853342..885728	32386

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-100)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 109 a.a.
• Molecular weight: 12978.31 Da
• Isoelectric Point: 4.7152

>T240177 WP_262516296.1 NZ_CP094752:875575-875901 [Staphylococcus aureus]
MNLEINDLFSDLKLLKDRFEDLKDNHGWHFDNFYPHEPNHVLNKTEAIKEGLSYHERRIHNNQMFDLFHLYIEQFDNIIE
KFHEIEKASSENFGEESDDAKNSIKVAE

Nucleotide

• Length: 327 bp

>T240177 NZ_LS992171:1786276-1786530 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCTCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCTACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8220.25 Da
• Isoelectric Point: 4.3718

>AT240177 WP_250406114.1 NZ_CP094752:875363-875572 [Staphylococcus aureus]
MNNEQKEVLEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELILKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT240177 NZ_LS992171:1786028-1786279 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA