Detailed information of TA system TA240055

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsdAT/-
• Location: 1653893..1654415
• Replicon: chromosome
• Accession: NZ_CP094717
• Organism: Staphylococcus sp. IVB6246

Toxin (Protein)

• Gene name: TsdT
• Uniprot ID: -
• Locus tag: MUA26_RS08275
• Protein ID: WP_262609113.1
• Coordinates: 1653893..1654114 (-)
• Length: 74 a.a.

Antitoxin (Protein)

• Gene name: TsdA
• Uniprot ID: -
• Locus tag: MUA26_RS08280
• Protein ID: WP_262603714.1
• Coordinates: 1654128..1654415 (-)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MUA26_RS08255 (MUA26_08235)	1649894..1651099	+	1206	WP_262603710.1	FtsW/RodA/SpoVE family cell cycle protein	-
MUA26_RS08260	1651180..1651320	-	141	WP_262605150.1	Lmo0850 family protein	-
MUA26_RS08265 (MUA26_08240)	1651406..1653586	-	2181	WP_262613977.1	heavy metal translocating P-type ATPase	-
MUA26_RS08270 (MUA26_08245)	1653687..1653890	-	204	WP_262603712.1	cation transporter	-
MUA26_RS08275 (MUA26_08250)	1653893..1654114	-	222	WP_262609113.1	heavy metal-associated domain-containing protein	Toxin
MUA26_RS08280 (MUA26_08255)	1654128..1654415	-	288	WP_262603714.1	copper-sensing transcriptional repressor CsoR	Antitoxin
MUA26_RS08285 (MUA26_08260)	1654559..1656049	+	1491	WP_262613978.1	cardiolipin synthase	-
MUA26_RS08290 (MUA26_08265)	1656070..1656720	+	651	WP_262613979.1	HD domain-containing protein	-
MUA26_RS08295 (MUA26_08270)	1656783..1657652	-	870	WP_262613980.1	membrane protein insertase YidC	-
MUA26_RS08300 (MUA26_08275)	1657741..1658379	-	639	WP_262605151.1	thiamine phosphate synthase	-
MUA26_RS08305 (MUA26_08280)	1658369..1659175	-	807	WP_262603718.1	hydroxyethylthiazole kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Heavy metal-associated domain, HMA (5-63)

Antitoxin

• Metal-sensitive transcriptional repressor (12-90)

Sequences

Toxin

Protein

• Length: 74 a.a.
• Molecular weight: 8299.26 Da
• Isoelectric Point: 4.1813

>T240055 WP_262609113.1 NZ_CP094717:c1654114-1653893 [Staphylococcus sp. IVB6246]
VHSKVWLSGLSSEEQKQQLESRLRDMIGVETAEVDIDKQIVILTYETPANLNTLEKEIYDAGYPVINSYKGED

Nucleotide

• Length: 222 bp

>T240055 NZ_LS483484:c2129880-2129704 [Staphylococcus aureus]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10929.52 Da
• Isoelectric Point: 6.6368

>AT240055 WP_262603714.1 NZ_CP094717:c1654415-1654128 [Staphylococcus sp. IVB6246]
MIEHANHSEVTKRNLQSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVASKLLEHHMKGCILHKVEGGNEQE
AMDELLVTFQKLMKD

Nucleotide

• Length: 288 bp

>AT240055 NZ_LS483484:2129581-2129636 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG