Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yefM-yoeB (relBE)/Txe-RelB |
| Location | 2451298..2451821 | Replicon | chromosome |
| Accession | NZ_CP094712 | ||
| Organism | Staphylococcus schleiferi strain IVB6183 | ||
Toxin (Protein)
| Gene name | yoeB | Uniprot ID | S2XCX2 |
| Locus tag | MUA40_RS11685 | Protein ID | WP_016425657.1 |
| Coordinates | 2451555..2451821 (+) | Length | 89 a.a. |
Antitoxin (Protein)
| Gene name | yefM | Uniprot ID | S2XXM7 |
| Locus tag | MUA40_RS11680 | Protein ID | WP_016425656.1 |
| Coordinates | 2451298..2451555 (+) | Length | 86 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MUA40_RS11630 (MUA40_11595) | 2446334..2446519 | + | 186 | WP_016425649.1 | hypothetical protein | - |
| MUA40_RS11635 (MUA40_11600) | 2446529..2446981 | + | 453 | WP_016425650.1 | DUF523 domain-containing protein | - |
| MUA40_RS11640 (MUA40_11605) | 2447196..2447420 | - | 225 | WP_167512896.1 | hypothetical protein | - |
| MUA40_RS11645 (MUA40_11610) | 2447435..2447596 | + | 162 | WP_228446226.1 | hypothetical protein | - |
| MUA40_RS11650 (MUA40_11615) | 2447716..2447928 | + | 213 | WP_231371820.1 | hypothetical protein | - |
| MUA40_RS11655 (MUA40_11620) | 2448033..2448368 | + | 336 | WP_257211757.1 | Msa family membrane protein | - |
| MUA40_RS11660 (MUA40_11625) | 2448419..2449231 | + | 813 | WP_231371814.1 | ABC transporter ATP-binding protein | - |
| MUA40_RS11665 (MUA40_11630) | 2449224..2449979 | + | 756 | WP_016425653.1 | hypothetical protein | - |
| MUA40_RS11670 (MUA40_11635) | 2449989..2450165 | + | 177 | WP_016425654.1 | hypothetical protein | - |
| MUA40_RS11675 (MUA40_11640) | 2450232..2451065 | + | 834 | WP_016425655.1 | CPBP family intramembrane metalloprotease | - |
| MUA40_RS11680 (MUA40_11645) | 2451298..2451555 | + | 258 | WP_016425656.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| MUA40_RS11685 (MUA40_11650) | 2451555..2451821 | + | 267 | WP_016425657.1 | Txe/YoeB family addiction module toxin | Toxin |
| MUA40_RS11690 (MUA40_11655) | 2452260..2452973 | - | 714 | WP_236249160.1 | ISL3 family transposase | - |
| MUA40_RS11695 (MUA40_11660) | 2452970..2453578 | - | 609 | WP_236249159.1 | transposase family protein | - |
| MUA40_RS11700 (MUA40_11665) | 2453866..2454402 | + | 537 | WP_016425660.1 | 4'-phosphopantetheinyl transferase superfamily protein | - |
| MUA40_RS11705 (MUA40_11670) | 2454408..2454908 | + | 501 | WP_016425661.1 | MepB family protein | - |
| MUA40_RS11710 (MUA40_11675) | 2455053..2455415 | + | 363 | WP_016425662.1 | transposase | - |
| MUA40_RS11715 (MUA40_11680) | 2455619..2456287 | - | 669 | WP_194368734.1 | saccharopine dehydrogenase NADP-binding domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 89 a.a. Molecular weight: 10646.09 Da Isoelectric Point: 9.7537
>T240037 WP_016425657.1 NZ_CP094712:2451555-2451821 [Staphylococcus schleiferi]
MSYYSVLIKNSAKSDLKKINKSHLKEQFLNVVETLKIDPYEPSQSFEKLQPKHLGRYSRRINHQHRVVYTVDDEKREVYI
FSTWSHYE
MSYYSVLIKNSAKSDLKKINKSHLKEQFLNVVETLKIDPYEPSQSFEKLQPKHLGRYSRRINHQHRVVYTVDDEKREVYI
FSTWSHYE
Download Length: 267 bp
>T240037 NZ_LS483473:462711-463004 [Pasteurella multocida]
ATGAGTAAGAAAAAAATAAAATTAAAACTGTTTGATATTGCTGAACATCTAGACAGTGAAGAAATGATTGCGGCATATTT
AAGTGAAGTTTTAGAAACATGTGATACTAATGAATTTATTTCCGCTTTAAGTGATGTTGTAAGAGCAAAAGGAATGACGG
AGTTAGCAGCAAAAACAGGGTTAAGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGCAAGCCACGTTTTGATACG
ATAATGAAAATTATGCATTCCTTAGGTATTAAACTTGTCCCAACGCACATCTAA
ATGAGTAAGAAAAAAATAAAATTAAAACTGTTTGATATTGCTGAACATCTAGACAGTGAAGAAATGATTGCGGCATATTT
AAGTGAAGTTTTAGAAACATGTGATACTAATGAATTTATTTCCGCTTTAAGTGATGTTGTAAGAGCAAAAGGAATGACGG
AGTTAGCAGCAAAAACAGGGTTAAGAAGAGAAAGCCTCTATAAAACATTATCATACGGTAGCAAGCCACGTTTTGATACG
ATAATGAAAATTATGCATTCCTTAGGTATTAAACTTGTCCCAACGCACATCTAA
Antitoxin
Download Length: 86 a.a. Molecular weight: 9781.91 Da Isoelectric Point: 5.1133
>AT240037 WP_016425656.1 NZ_CP094712:2451298-2451555 [Staphylococcus schleiferi]
MNIKTPTNARKEFYELLKHVNVNHEPVIISGSKSENNAVIVSQKDWNSIQETLFLESTGTMDKVRKREKDDSGYTNIEDL
DWGNL
MNIKTPTNARKEFYELLKHVNVNHEPVIISGSKSENNAVIVSQKDWNSIQETLFLESTGTMDKVRKREKDDSGYTNIEDL
DWGNL
Download Length: 258 bp
>AT240037 NZ_LS483473:462430-462714 [Pasteurella multocida]
GTGGGTCGGTTAAAGGAGGTAAAAATTTTATCCGCCAAATCTGCTGTTCTTGCTCGTATTAACAAAGCAATGAATGGTAA
TTTTGGCGATCATAAATCGATTGGAAATGGATTGTATGAGATGAGAATTATAAAAGGTTCGGGTTATAGAGTTTACTATG
GACAATATAGAGAAGTAACTTATTTATTAATTTGTGGTGGCGATAAATCAACACAGAAATCAGACATTGTTAAAGCGAGA
GAGTTGTGGAAAGAAATAAAGCAACAAGAGGAAGTAAAAGTATGA
GTGGGTCGGTTAAAGGAGGTAAAAATTTTATCCGCCAAATCTGCTGTTCTTGCTCGTATTAACAAAGCAATGAATGGTAA
TTTTGGCGATCATAAATCGATTGGAAATGGATTGTATGAGATGAGAATTATAAAAGGTTCGGGTTATAGAGTTTACTATG
GACAATATAGAGAAGTAACTTATTTATTAATTTGTGGTGGCGATAAATCAACACAGAAATCAGACATTGTTAAAGCGAGA
GAGTTGTGGAAAGAAATAAAGCAACAAGAGGAAGTAAAAGTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|