Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1821358..1821880 Replicon chromosome
Accession NZ_CP094321
Organism Edwardsiella anguillarum strain 43473

Toxin (Protein)


Gene name relE Uniprot ID C5BBL4
Locus tag MQ094_RS08465 Protein ID WP_015871319.1
Coordinates 1821358..1821639 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C5BBL3
Locus tag MQ094_RS08470 Protein ID WP_015871318.1
Coordinates 1821629..1821880 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQ094_RS08450 (MQ094_08440) 1816745..1817521 + 777 WP_283294719.1 hypothetical protein -
MQ094_RS08455 (MQ094_08445) 1817514..1819175 + 1662 WP_283294840.1 terminase -
MQ094_RS08460 (MQ094_08450) 1819172..1821286 + 2115 WP_283294720.1 portal protein -
MQ094_RS08465 (MQ094_08455) 1821358..1821639 - 282 WP_015871319.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MQ094_RS08470 (MQ094_08460) 1821629..1821880 - 252 WP_015871318.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MQ094_RS08475 (MQ094_08465) 1822168..1822659 + 492 WP_283294721.1 hypothetical protein -
MQ094_RS08480 (MQ094_08470) 1822646..1822960 + 315 WP_283294722.1 hypothetical protein -
MQ094_RS08485 (MQ094_08475) 1823365..1825239 + 1875 WP_045427621.1 PhoX family phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1786423..1836442 50019


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10783.62 Da        Isoelectric Point: 10.6993

>T239621 WP_015871319.1 NZ_CP094321:c1821639-1821358 [Edwardsiella anguillarum]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Download         Length: 282 bp

>T239621 NZ_LS483259:1311118-1312458 [Bordetella pertussis]
ATGGGGCGCCGATCGCACAGCCGCAGCCTGTCCATCTGGACCAACGGCGTTCGCGTCGGGCGTTGGACGGTTCCCGCTCG
CGGAGAGATGGAACTGCAGTACGACGTGGATTGGGTCCGTGCCGACGTCGGCCGGCCACTTTCGCTGTCGCTGCCATTCA
ACTTGCAGAATCTGCCCCTCAAGGGGGAGAGAGTCGCCAACTACTTCGACAATCTGCTACCGGACAGCGACGCTATCCGT
CGTCGCGTGGCCGAGCGATTCAGGACGGGCTCGGTCGATCCCTTCGATCTGTTGAAAGCCATTGGACGCGATTGCGTTGG
CGCCGTACAGATCCTGGAAGACGAAGAGATACCTGAGGGCTTTGATCGCATCGAGGGCGTGCCTCTGTCCGAGGAGGACA
TCGAGCGGCATTTGATCGAAACCGTTACGCCGCGCGCCTTCGCTGCGGGCCGGGACCCGGACGCGGATTTCAGAATTTCT
CTGGCCGGCGCGCAAGAGAAGACAGCCTTCCTGTGGTGGGGCGGACAGTGGCTTGCGCCGCGTGGCGCGACATCGACGAG
CCATATTTTCAAACTTCCATTGGGCTTGGTGGGTGGACGGCGGGCTGACTTCAGCACTTCTGTTGATAACGAATGGCTGT
GTCTGAAGCTGCTGAAGGCGTATGGGTTGGATGTGGCTGAGGCCAGCATCGCAACCTTCGGACAGCAGCGAGTGCTGGTG
GTCGAGCGATTCGACCGGCGTGTTGCGCCCAACGGGCAATGGCTGATGCGCCTGCCGCAGGAAGATTTCTGCCAGGTCGA
GGGGTGCTCGCCGCTACGCAAGTATGAAAACGAGGGCGGCCCAGGACTCAAGGCCTTATTCGCCACGCTGCGGCAGTCAG
TGAACGCAGCGGTCGATATGAGAACGTTGATGGCGGCGCAGATCCTGTTTTGGTTGCTGCGGGCACCCGATGGCCACGCC
AAGAATTTCAGCATCCAGTTGTTGCCGCGCGGCCGTTTCCAGTTGACTAGACTGTACGACGTGATGTCGGCCTATCCGGT
ACTGGGCGATGGCGCGAATCAGTGGTCGCCGTTCGAAATCAAATTGGCGATGGCATTGATTGGCAAGAACCGGCATTACG
AGATGCACGGCATCCAGCGCAGGCACTTCAACAGCACCGCACAAAAAGTTGGTTATGGCCCGACGGCGGAGCCGATCATT
GAAGACCTGTTGGCCCGTACGCCCGCGATCATTGCCGCCGTGCAGGCCGATTTGCCGCAGGACTTCTCGCCGCGTGTTGC
GGACTCCGTCCTGGGTGGGCTTGCGCAGGCCGCAAAGTCGCTCGGCGCAATGATGCCGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9155.24 Da        Isoelectric Point: 3.7550

>AT239621 WP_015871318.1 NZ_CP094321:c1821880-1821629 [Edwardsiella anguillarum]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Download         Length: 252 bp

>AT239621 NZ_LS483259:1310859-1311116 [Bordetella pertussis]
ATGCCGCCGCCATCACAACCTCTGCTCACTACCGGCCAGCTTGGCGCGGTCTTGCAGGCTGCACGCAAAGCACAGGGACT
GACTCAATCGGCCCTGGCCAGTCGTATCGGCCTGAGCCAATCGCGGGTCTCGCACCTGGAGTTGAATGCCCATCAACTGA
GCGTGGAGCAGCTCCTGGCCTGGTGCGCGGCGCTAGGGTTGGAGTTGACGATTGCGACTCGCGGAAGTCCCGCAGGGTCT
TCCGACGCGGATTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C5BBL4

Antitoxin

Source ID Structure
AlphaFold DB C5BBL3

References