Detailed information of TA system TA239543

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1901575..1902097
• Replicon: chromosome
• Accession: NZ_CP094311
• Organism: Edwardsiella anguillarum strain R18-14-2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: MQ082_RS09025
• Protein ID: WP_015871319.1
• Coordinates: 1901575..1901856 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: MQ082_RS09030
• Protein ID: WP_015871318.1
• Coordinates: 1901846..1902097 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQ082_RS09005 (MQ082_08995)	1896976..1897194	+	219	WP_225865175.1	hypothetical protein	-
MQ082_RS09010 (MQ082_09000)	1897356..1897751	+	396	WP_225865176.1	hypothetical protein	-
MQ082_RS09015 (MQ082_09005)	1897744..1899405	+	1662	WP_049703944.1	terminase	-
MQ082_RS09020 (MQ082_09015)	1899402..1901503	+	2102	Protein_1731	portal protein	-
MQ082_RS09025 (MQ082_09020)	1901575..1901856	-	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MQ082_RS09030 (MQ082_09025)	1901846..1902097	-	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MQ082_RS09035 (MQ082_09030)	1902385..1902876	+	492	WP_225865179.1	hypothetical protein	-
MQ082_RS09040 (MQ082_09035)	1902863..1903210	+	348	WP_144242832.1	hypothetical protein	-
MQ082_RS09045 (MQ082_09040)	1903582..1905456	+	1875	WP_034165826.1	PhoX family phosphatase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1868881..1916207	47326

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T239543 WP_015871319.1 NZ_CP094311:c1901856-1901575 [Edwardsiella anguillarum]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T239543 NZ_LR898874:c2116818-2116324 [Escherichia coli]
ATGATTCAGGCCCCCGAGCCACTCATGGCAAGGCATCAATTCACCTCTTTTTGCTCGGGAGTAGAAACGATGGATAACTG
GCTAAAGCAGAGAGCCCTAAAAAATCAGCTTGCCGGCGCATCACGTACATTTGTTAGCTGTGATACGTATAGCAACGTTT
TGGCATATTATTCGCTTGCTTCCAGCGCCGTTGAAACGTATGTCGCGACAGGACGATTTCGCCGAAATATGCCAGAACCG
ATCCCTGTTGTAGTACTTGGTCGTCTGGCAATAGATAAATCATTACAGGGTCAGGGCATCGGTCGTGCGATGGTCAGAGA
TGCCGGTCTACGAGTACTACAGGCGGCTGAAGTCATTGGTATTCGCGGAATGTTGGTCCATGCGTTATCAGACCAGGCCC
GTGAGTTTTATCTGCGAGTGGGGTTTGAACCATCGCCTGTCGATTCTATGATACTGATGGCAACATTGGCTGATTTGCAG
GAATGTCTTAAATAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT239543 WP_015871318.1 NZ_CP094311:c1902097-1901846 [Edwardsiella anguillarum]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT239543 NZ_LR898874:c2117108-2116815 [Escherichia coli]
ATGCCAGCAGCCAATAACATTCCAGCCAGGCGCGAATCTTTAAACTTGCGCATAAAACCCGCAGAACGCGATCTTATTGA
CCGGGCCGCTAAAGCCCGAGGAAAAAATCGCACCGAATTTGTCCTTGAGGCCGCCAGAGCCGCAGCTGAAGAGGCGCTCA
TTGAGCAGAGAATTTTCAGGATCGATTCTGATGATTACCAGCTATTTTTGAATCGTCTGGATCAGCCCCCCGCGCCCAAT
GCTGCATTACGCAAAACCATGCAAACACCCGCGCCGTGGGAGCAAAAAAAATGA

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3