Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 1901477..1901999 Replicon chromosome
Accession NZ_CP094306
Organism Edwardsiella anguillarum strain R18-14-13

Toxin (Protein)


Gene name relE Uniprot ID C5BBL4
Locus tag MQ091_RS09025 Protein ID WP_015871319.1
Coordinates 1901477..1901758 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C5BBL3
Locus tag MQ091_RS09030 Protein ID WP_015871318.1
Coordinates 1901748..1901999 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MQ091_RS09005 (MQ091_08995) 1896878..1897096 + 219 WP_225865175.1 hypothetical protein -
MQ091_RS09010 (MQ091_09000) 1897258..1897653 + 396 WP_225865176.1 hypothetical protein -
MQ091_RS09015 (MQ091_09005) 1897646..1899307 + 1662 WP_049703944.1 terminase -
MQ091_RS09020 (MQ091_09015) 1899304..1901405 + 2102 Protein_1731 portal protein -
MQ091_RS09025 (MQ091_09020) 1901477..1901758 - 282 WP_015871319.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MQ091_RS09030 (MQ091_09025) 1901748..1901999 - 252 WP_015871318.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MQ091_RS09035 (MQ091_09030) 1902287..1902778 + 492 WP_225865179.1 hypothetical protein -
MQ091_RS09040 (MQ091_09035) 1902765..1903112 + 348 WP_144242832.1 hypothetical protein -
MQ091_RS09045 (MQ091_09040) 1903484..1905358 + 1875 WP_034165826.1 PhoX family phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1868783..1916109 47326


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10783.62 Da        Isoelectric Point: 10.6993

>T239516 WP_015871319.1 NZ_CP094306:c1901758-1901477 [Edwardsiella anguillarum]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Download         Length: 282 bp

>T239516 NZ_LR898868:711191-711487 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9155.24 Da        Isoelectric Point: 3.7550

>AT239516 WP_015871318.1 NZ_CP094306:c1901999-1901748 [Edwardsiella anguillarum]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Download         Length: 252 bp

>AT239516 NZ_LR898868:711489-711884 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C5BBL4

Antitoxin

Source ID Structure
AlphaFold DB C5BBL3

References