Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4110089..4110605 Replicon chromosome
Accession NZ_CP094269
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain JL228

Toxin (Protein)


Gene name relE Uniprot ID B5R9I9
Locus tag MPK88_RS20205 Protein ID WP_000220582.1
Coordinates 4110089..4110373 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag MPK88_RS20210 Protein ID WP_000212724.1
Coordinates 4110363..4110605 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPK88_RS20190 (4105300) 4105300..4106952 + 1653 WP_000155048.1 alpha,alpha-phosphotrehalase -
MPK88_RS20195 (4107361) 4107361..4109499 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
MPK88_RS20200 (4109621) 4109621..4110085 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MPK88_RS20205 (4110089) 4110089..4110373 - 285 WP_000220582.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MPK88_RS20210 (4110363) 4110363..4110605 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MPK88_RS20215 (4110683) 4110683..4112596 - 1914 WP_001212142.1 BglG family transcription antiterminator -
MPK88_RS20220 (4112613) 4112613..4113353 - 741 WP_000779259.1 KDGP aldolase family protein -
MPK88_RS20225 (4113350) 4113350..4114468 - 1119 WP_001139169.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MPK88_RS20230 (4114452) 4114452..4115585 - 1134 WP_000459957.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10912.66 Da        Isoelectric Point: 9.6743

>T239416 WP_000220582.1 NZ_CP094269:c4110373-4110089 [Salmonella enterica subsp. enterica serovar Enteritidis]
MTYELEFDPRALKEWHKLGDTVQAQLKKKLADVLLNPRIDSARLNDLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T239416 NZ_LR890714:261830-261937 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT239416 WP_000212724.1 NZ_CP094269:c4110605-4110363 [Salmonella enterica subsp. enterica serovar Enteritidis]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT239416 NZ_LR890714:c261781-261718 [Escherichia coli]
GTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656ILJ8

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References