Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) DinJ-YafQ (relBE)/YafQ-RelB
Location 358872..359410 Replicon chromosome
Accession NZ_CP094269
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain JL228

Toxin (Protein)


Gene name yafQ Uniprot ID M7RHM1
Locus tag MPK88_RS01620 Protein ID WP_001526148.1
Coordinates 359135..359410 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID M7RMV7
Locus tag MPK88_RS01615 Protein ID WP_000729713.1
Coordinates 358872..359132 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPK88_RS01600 (354625) 354625..356178 + 1554 WP_000013013.1 TROVE domain-containing protein -
MPK88_RS01605 (356526) 356526..357740 + 1215 WP_001105533.1 RNA-splicing ligase RtcB -
MPK88_RS01610 (357744) 357744..358763 + 1020 WP_000101024.1 RNA 3'-terminal phosphate cyclase -
MPK88_RS01615 (358872) 358872..359132 + 261 WP_000729713.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MPK88_RS01620 (359135) 359135..359410 + 276 WP_001526148.1 type II toxin-antitoxin system YafQ family toxin Toxin
MPK88_RS01625 (359498) 359498..362203 - 2706 WP_000907030.1 HTH-type transcriptional regulator MalT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(4-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-84)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10739.34 Da        Isoelectric Point: 8.8652

>T239396 WP_001526148.1 NZ_CP094269:359135-359410 [Salmonella enterica subsp. enterica serovar Enteritidis]
MGQREIEYSGQFQKDVKRAQKRHKDVGKLKTLMTLLIHHPFPLPAIYKDHPLQGSYSGYRDAHIEPDWILIYKITDECLR
FERTGTHADLF

Download         Length: 276 bp

>T239396 NZ_LR890702:c4955799-4955581 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9446.80 Da        Isoelectric Point: 4.4734

>AT239396 WP_000729713.1 NZ_CP094269:358872-359132 [Salmonella enterica subsp. enterica serovar Enteritidis]
MAANALVRARIDETLKDQAADVLAEMGLTISDLIRITLTKVAREKALPFDLRIPNELTSRTIENSEAGVDIHKAKDADDL
FDQLGI

Download         Length: 261 bp

>AT239396 NZ_LR890702:c4956200-4955826 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3V4SM83

Antitoxin

Source ID Structure
AlphaFold DB A0A4D6P2L2

References