Detailed information of TA system TA239165

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 143681..144186
• Replicon: chromosome
• Accession: NZ_CP093967
• Organism: Pseudomonas aeruginosa strain NY4605

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: MO986_RS00665
• Protein ID: WP_003083773.1
• Coordinates: 143681..143962 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: MO986_RS00670
• Protein ID: WP_003083775.1
• Coordinates: 143959..144186 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MO986_RS00640 (MO986_00640)	138932..140281	+	1350	WP_003119513.1	C4-dicarboxylate transporter DctA	-
MO986_RS00645 (MO986_00645)	140330..141016	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
MO986_RS00650 (MO986_00650)	141117..141851	+	735	WP_003117208.1	GntR family transcriptional regulator	-
MO986_RS00655 (MO986_00655)	142031..142441	+	411	WP_003101225.1	aegerolysin family protein	-
MO986_RS00660 (MO986_00660)	142473..143381	-	909	WP_016561475.1	LysR family transcriptional regulator	-
MO986_RS00665 (MO986_00665)	143681..143962	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
MO986_RS00670 (MO986_00670)	143959..144186	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
MO986_RS00675 (MO986_00675)	144362..144982	-	621	WP_003101226.1	hypothetical protein	-
MO986_RS00680 (MO986_00680)	145083..145583	+	501	WP_003112629.1	LEA type 2 family protein	-
MO986_RS00685 (MO986_00685)	145656..145997	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
MO986_RS00690 (MO986_00690)	146079..147506	-	1428	WP_033998141.1	GABA permease	-
MO986_RS00695 (MO986_00695)	147675..149168	-	1494	WP_003101230.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T239165 WP_003083773.1 NZ_CP093967:c143962-143681 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T239165 NZ_LR890620:c4618952-4618419 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCTGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT239165 WP_003083775.1 NZ_CP093967:c144186-143959 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT239165 NZ_LR890620:c4619229-4618963 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
GGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9