Detailed information of TA system TA239149

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-ratA/-
• Location: 995627..995850
• Replicon: chromosome
• Accession: NZ_CP093957
• Organism: Enterococcus faecalis strain NY13321

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: -
• Locus tag: MPM64_RS04710
• Protein ID: WP_075551663.1
• Coordinates: 995627..995728 (+)
• Length: 34 a.a.

Antitoxin (RNA)

Gene name	ratA
Locus tag	-
Coordinates	995673..995850 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MPM64_RS04690	990849..991247	+	399	WP_002354951.1	glyoxalase	-
MPM64_RS04695	991298..992194	-	897	WP_002368434.1	YitT family protein	-
MPM64_RS04700	992497..992997	-	501	WP_002370089.1	cysteine hydrolase family protein	-
MPM64_RS04705	993168..995438	+	2271	WP_002370088.1	bifunctional glutamate--cysteine ligase/glutathione synthetase	-
MPM64_RS04710	995627..995728	+	102	WP_075551663.1	putative holin-like toxin	Toxin
-	995673..995850	-	178	-	-	Antitoxin
MPM64_RS04715	995913..996365	-	453	WP_002354958.1	YueI family protein	-
MPM64_RS04720	996550..997497	+	948	WP_002354960.1	iron chelate uptake ABC transporter family permease subunit	-
MPM64_RS04725	997494..998459	+	966	WP_002354961.1	iron chelate uptake ABC transporter family permease subunit	-
MPM64_RS04730	998456..999211	+	756	WP_002354962.1	ATP-binding cassette domain-containing protein	-
MPM64_RS04735	999250..1000203	+	954	WP_002370087.1	siderophore ABC transporter substrate-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (1-33)

Sequences

Toxin

Protein

• Length: 34 a.a.
• Molecular weight: 3599.34 Da
• Isoelectric Point: 4.5869

>T239149 WP_075551663.1 NZ_CP093957:995627-995728 [Enterococcus faecalis]
MSIEAALELMISFAAFVALLIFGILEATKNDKK

Nucleotide

• Length: 102 bp

>T239149 NZ_LR890616:c4736317-4736033 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCTGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGGCCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin

Nucleotide

• Length: 178 bp

>AT239149 NZ_CP093957:c995850-995673 [Enterococcus faecalis]
AAAAGAGAGGTATGCGGGTACATACCTCTCTTTTATACCAGCGCCAGTTATAAGAACTGGTGGCTTACTGAGTTAAGTTT
TTATTACTGTTTAACCGTTCGGCCTGTCAAGCTTATGAACGGTTATTTTTTATCGTTTTTCGTTGCTTCAAGGATACCGA
AAATCAGTAGTGCAACAA

Structures

Antitoxin