Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) txpA-ratA/-
Location 844533..844870 Replicon chromosome
Accession NZ_CP093957
Organism Enterococcus faecalis strain NY13321

Toxin (Protein)


Gene name txpA Uniprot ID A0A1J6YG70
Locus tag MPM64_RS04035 Protein ID WP_002396786.1
Coordinates 844727..844870 (-) Length 48 a.a.

Antitoxin (RNA)


Gene name ratA
Locus tag -
Coordinates 844533..844795 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPM64_RS04030 839841..844532 + 4692 WP_010815866.1 WxL domain-containing protein -
- 844533..844795 + 263 - - Antitoxin
MPM64_RS04035 844727..844870 - 144 WP_002396786.1 putative holin-like toxin Toxin
MPM64_RS04040 845200..846816 - 1617 WP_002370154.1 phosphatase PAP2/LCP family protein -
MPM64_RS04045 847278..848573 + 1296 WP_010815865.1 ATP-binding protein -
MPM64_RS04050 848582..849214 + 633 WP_002358972.1 RloB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Small toxic protein BsrE-like

(14-47)


Sequences

Toxin        


Download         Length: 48 a.a.        Molecular weight: 5203.19 Da        Isoelectric Point: 8.6626

>T239144 WP_002396786.1 NZ_CP093957:c844870-844727 [Enterococcus faecalis]
MNVSTKIYERRGLLSIAEALALMISFGSFIATLIFGILEAVKEDNKK

Download         Length: 144 bp

>T239144 NZ_LR890616:1951132-1951234 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 263 bp

>AT239144 NZ_CP093957:844533-844795 [Enterococcus faecalis]
AAATAAAAATGCCCGAGCCTCTTATTTTTCTAAGGCTCGGGCATTTTTATTGATGGTCTTTTGAGGGTCGTTGTGCTATA
ATGGTAATGAAAAGAGAGGTATGCGCCAACATACCTCTCTAGTGTAGAGCCGTTTCAGACGGTAGCGATTTTTAGTGATT
TATAAAAAATAACCGTGCTCGCTAAAGTTGACGGTTATTTTTTATTGTCTTCTTTAACAGCCTCTAGGATTCCGAAGATT
AACGTTGCGATAAAAGAACCGAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1J6YG70

Antitoxin

Download structure file

References