Detailed information of TA system TA239092

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-MW1433/-
• Location: 2066416..2066723
• Replicon: chromosome
• Accession: NZ_CP093933
• Organism: Staphylococcus aureus strain WA121-2021_15363

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: MQP45_RS10330
• Protein ID: WP_011447039.1
• Coordinates: 2066547..2066723 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	MW1433
Locus tag	-
Coordinates	2066416..2066555 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MQP45_RS10290 (2061754)	2061754..2062014	+	261	WP_001791826.1	hypothetical protein	-
MQP45_RS10295 (2062067)	2062067..2062417	-	351	WP_103150232.1	complement inhibitor SCIN-A	-
MQP45_RS10300 (2063102)	2063102..2063551	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
MQP45_RS10305 (2063646)	2063646..2063981	-	336	Protein_1994	SH3 domain-containing protein	-
MQP45_RS10310 (2064631)	2064631..2065122	-	492	WP_000920037.1	staphylokinase	-
MQP45_RS10315 (2065314)	2065314..2066069	-	756	WP_000861038.1	CHAP domain-containing protein	-
MQP45_RS10320 (2066081)	2066081..2066335	-	255	WP_000611512.1	phage holin	-
MQP45_RS10325 (2066387)	2066387..2066494	+	108	WP_001791821.1	hypothetical protein	-
- (2066416)	2066416..2066555	+	140	NuclAT_0	-	Antitoxin
- (2066416)	2066416..2066555	+	140	NuclAT_0	-	Antitoxin
- (2066416)	2066416..2066555	+	140	NuclAT_0	-	Antitoxin
- (2066416)	2066416..2066555	+	140	NuclAT_0	-	Antitoxin
MQP45_RS10330 (2066547)	2066547..2066723	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
MQP45_RS10335 (2066873)	2066873..2067169	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
MQP45_RS10340 (2067227)	2067227..2067514	-	288	WP_001040261.1	hypothetical protein	-
MQP45_RS10345 (2067561)	2067561..2067713	-	153	WP_001153681.1	hypothetical protein	-
MQP45_RS10350 (2067703)	2067703..2071488	-	3786	WP_103150169.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2062067..2116569	54502

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T239092 WP_011447039.1 NZ_CP093933:c2066723-2066547 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T239092 NZ_LR890603:1828435-1828686 [Escherichia coli]
ATGCGTACAATTAGTTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Nucleotide

• Length: 140 bp

>AT239092 NZ_CP093933:2066416-2066555 [Staphylococcus aureus]
ATATATAGAAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTGGCTATTTTAGATTAAA
GATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGATGGTTATTTTTT

Structures

Toxin

• PDB: 7NS1

Antitoxin