Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 2564394..2565087 Replicon chromosome
Accession NZ_CP093548
Organism Escherichia coli strain YL03

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag MPJ80_RS12575 Protein ID WP_000415584.1
Coordinates 2564791..2565087 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag MPJ80_RS12570 Protein ID WP_000650107.1
Coordinates 2564394..2564789 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPJ80_RS12560 (2560258) 2560258..2562516 - 2259 WP_024249834.1 DNA topoisomerase IV subunit A -
MPJ80_RS12565 (2562654) 2562654..2564261 - 1608 WP_001295629.1 ABC transporter substrate-binding protein -
MPJ80_RS12570 (2564394) 2564394..2564789 - 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
MPJ80_RS12575 (2564791) 2564791..2565087 - 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
MPJ80_RS12580 (2565292) 2565292..2565774 - 483 WP_000183505.1 GyrI-like domain-containing protein -
MPJ80_RS12585 (2565827) 2565827..2566219 - 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
MPJ80_RS12590 (2566371) 2566371..2567030 + 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
MPJ80_RS12595 (2567027) 2567027..2568376 + 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
MPJ80_RS12600 (2568422) 2568422..2568754 - 333 WP_023149630.1 DUF2645 family protein -
MPJ80_RS12605 (2569073) 2569073..2569654 + 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
MPJ80_RS12610 (2569685) 2569685..2569999 + 315 WP_000958598.1 putative quinol monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase toxin MqsR

(5-97)

Antitoxin

Zinc finger, MqsA-type

(3-47)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T238876 WP_000415584.1 NZ_CP093548:c2565087-2564791 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T238876 NZ_LR890516:c55378-54962 [Klebsiella pneumoniae]
GTGAACAAAATCTATATGCTCGACACGAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTGCTGAAGCGCCT
GGAGCAGGCGGTGCTGCGGGGTCACCGCATTGTGGTTTCGGCCATTACCTACGCCGAGATGCGCTTCGGCGCCACCGGGC
CGAAGGCCGCGCCGCGTCACGTCCAGCTGGTTGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGCATGGCCGGCACGCCGATTGGCCCGAACGACACGGCGATTGC
CGGACACGCCATCGCCGCCGGCGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTGCCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT238876 WP_000650107.1 NZ_CP093548:c2564789-2564394 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT238876 NZ_LR890516:c55605-55375 [Klebsiella pneumoniae]
ATGCGCACAGTCTCTATTTTTAAAAACGGCAACAACCGCGCCATCCGTCTGCCCCGCGATCTGGATTTTGAGGGGGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTCG
AAAAAGCTGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGGGTTAACCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3HI2

Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References