Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2302409..2303063 Replicon chromosome
Accession NZ_CP093548
Organism Escherichia coli strain YL03

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag MPJ80_RS11295 Protein ID WP_000244781.1
Coordinates 2302409..2302816 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag MPJ80_RS11300 Protein ID WP_000354046.1
Coordinates 2302797..2303063 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPJ80_RS11275 (2298366) 2298366..2300099 - 1734 WP_000813232.1 single-stranded-DNA-specific exonuclease RecJ -
MPJ80_RS11280 (2300105) 2300105..2300815 - 711 WP_000715223.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MPJ80_RS11285 (2300840) 2300840..2301736 - 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
MPJ80_RS11290 (2301848) 2301848..2302369 + 522 WP_001055874.1 flavodoxin FldB -
MPJ80_RS11295 (2302409) 2302409..2302816 - 408 WP_000244781.1 protein YgfX Toxin
MPJ80_RS11300 (2302797) 2302797..2303063 - 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
MPJ80_RS11305 (2303315) 2303315..2304295 + 981 WP_000886102.1 tRNA-modifying protein YgfZ -
MPJ80_RS11310 (2304491) 2304491..2305150 - 660 WP_000250283.1 hemolysin III family protein -
MPJ80_RS11315 (2305314) 2305314..2305625 - 312 WP_001182943.1 N(4)-acetylcytidine aminohydrolase -
MPJ80_RS11320 (2305670) 2305670..2307103 + 1434 WP_001605840.1 6-phospho-beta-glucosidase BglA -
MPJ80_RS11325 (2307160) 2307160..2307903 - 744 WP_000951966.1 SDR family oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T238873 WP_000244781.1 NZ_CP093548:c2302816-2302409 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

>T238873 NZ_LR890515:4348184-4348717 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCGGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGATTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT238873 WP_000354046.1 NZ_CP093548:c2303063-2302797 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT238873 NZ_LR890515:4347907-4348173 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References