Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1324282..1325113 Replicon chromosome
Accession NZ_CP093548
Organism Escherichia coli strain YL03

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag MPJ80_RS06790 Protein ID WP_000854814.1
Coordinates 1324739..1325113 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag MPJ80_RS06785 Protein ID WP_001285585.1
Coordinates 1324282..1324650 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MPJ80_RS06745 (1320009) 1320009..1320104 - 96 Protein_1330 IS66 family insertion sequence element accessory protein TnpB -
MPJ80_RS06750 (1320198) 1320198..1321426 + 1229 WP_102384962.1 IS3 family transposase -
MPJ80_RS06755 (1321438) 1321438..1321656 - 219 Protein_1332 IS66 family insertion sequence element accessory protein TnpB -
MPJ80_RS06760 (1321714) 1321714..1321947 + 234 WP_001119729.1 DUF905 family protein -
MPJ80_RS06765 (1322047) 1322047..1322865 + 819 WP_032250973.1 DUF932 domain-containing protein -
MPJ80_RS06770 (1322947) 1322947..1323426 + 480 WP_089551765.1 antirestriction protein -
MPJ80_RS06775 (1323442) 1323442..1323918 + 477 WP_001186193.1 RadC family protein -
MPJ80_RS06780 (1323987) 1323987..1324208 + 222 WP_000692323.1 DUF987 domain-containing protein -
MPJ80_RS06785 (1324282) 1324282..1324650 + 369 WP_001285585.1 type IV toxin-antitoxin system cytoskeleton bundling-enhancing antitoxin CbeA Antitoxin
MPJ80_RS06790 (1324739) 1324739..1325113 + 375 WP_000854814.1 type IV toxin-antitoxin system cytoskeleton-binding toxin CbtA Toxin
MPJ80_RS06795 (1325110) 1325110..1325304 + 195 WP_000988600.1 DUF5983 family protein -
MPJ80_RS06800 (1325350) 1325350..1325430 + 81 Protein_1341 hypothetical protein -
MPJ80_RS06805 (1325719) 1325719..1325847 - 129 Protein_1342 transposase domain-containing protein -
MPJ80_RS06810 (1325967) 1325967..1326101 + 135 WP_001297944.1 EutP/PduV family microcompartment system protein -
MPJ80_RS06815 (1326202) 1326202..1326531 - 330 WP_000450409.1 DUF496 family protein -
MPJ80_RS06820 (1326703) 1326703..1327761 - 1059 WP_001200891.1 FUSC family protein -
MPJ80_RS06825 (1327959) 1327959..1328432 - 474 WP_001105415.1 DNA gyrase inhibitor SbmC -
MPJ80_RS06830 (1328551) 1328551..1329717 - 1167 WP_000830156.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T238869 WP_000854814.1 NZ_CP093548:1324739-1325113 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T238869 NZ_LR890515:c2800430-2800020 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATAGCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT238869 WP_001285585.1 NZ_CP093548:1324282-1324650 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT238869 NZ_LR890515:c2800677-2800411 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References