Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3821110..3821729 Replicon chromosome
Accession NZ_CP093489
Organism Klebsiella pneumoniae strain VA126

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag MO410_RS18760 Protein ID WP_002892050.1
Coordinates 3821511..3821729 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag MO410_RS18755 Protein ID WP_002892066.1
Coordinates 3821110..3821484 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MO410_RS18745 (3816262) 3816262..3817455 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MO410_RS18750 (3817478) 3817478..3820624 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit AcrB -
MO410_RS18755 (3821110) 3821110..3821484 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
MO410_RS18760 (3821511) 3821511..3821729 + 219 WP_002892050.1 HHA domain-containing protein Toxin
MO410_RS18765 (3821888) 3821888..3822454 + 567 WP_002892030.1 maltose O-acetyltransferase -
MO410_RS18770 (3822426) 3822426..3822566 - 141 WP_004147370.1 hypothetical protein -
MO410_RS18775 (3822587) 3822587..3823057 + 471 WP_002892026.1 YlaC family protein -
MO410_RS18780 (3823032) 3823032..3824483 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
MO410_RS18785 (3824584) 3824584..3825282 + 699 WP_080899866.1 GNAT family protein -
MO410_RS18790 (3825279) 3825279..3825419 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
MO410_RS18795 (3825419) 3825419..3825682 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T238767 WP_002892050.1 NZ_CP093489:3821511-3821729 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T238767 NZ_LR890471:357948-358295 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATACCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTTTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGCGGACAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT238767 WP_002892066.1 NZ_CP093489:3821110-3821484 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT238767 NZ_LR890471:358295-358594 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References