Detailed information of TA system TA238483

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3836396..3836810
• Replicon: chromosome
• Accession: NZ_CP093402
• Organism: Salmonella enterica subsp. enterica serovar Agona strain R21.0464

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: B5F8Y1
• Locus tag: MOP58_RS19010
• Protein ID: WP_000994221.1
• Coordinates: 3836553..3836810 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3836396..3836774 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOP58_RS18980	3831719..3832216	-	498	WP_000835844.1	Saf-pilin pilus formation protein SafA	-
MOP58_RS18985	3832977..3833681	-	705	Protein_3727	integrase core domain-containing protein	-
MOP58_RS18990	3833765..3833914	+	150	WP_151273333.1	type I toxin-antitoxin system SymE family toxin	-
MOP58_RS18995	3834046..3834324	-	279	WP_077905764.1	hypothetical protein	-
MOP58_RS19000	3834642..3835109	-	468	WP_000828177.1	sugar tyrosine-protein kinase	-
MOP58_RS19005	3835926..3836345	-	420	WP_130549555.1	hypothetical protein	-
-	3836396..3836774	-	379	-	-	Antitoxin
MOP58_RS19010	3836553..3836810	+	258	WP_000994221.1	SymE family type I addiction module toxin	Toxin
MOP58_RS19015	3836877..3837308	-	432	WP_023135248.1	hypothetical protein	-
MOP58_RS19020	3837380..3837796	-	417	WP_001748027.1	DUF2195 family protein	-
MOP58_RS19025	3837793..3838161	-	369	Protein_3735	hypothetical protein	-
MOP58_RS19030	3838160..3838225	+	66	Protein_3736	hypothetical protein	-
MOP58_RS19035	3838475..3838660	-	186	Protein_3737	transposase	-
MOP58_RS19040	3838760..3839431	-	672	WP_000058649.1	ankyrin repeat domain-containing protein	-
MOP58_RS19045	3839447..3839932	-	486	WP_000103455.1	hypothetical protein	-
MOP58_RS19050	3840274..3840510	+	237	WP_130549554.1	hypothetical protein	-
MOP58_RS19055	3840592..3840768	+	177	Protein_3741	phage integrase N-terminal domain-containing protein	-
MOP58_RS19060	3841236..3841598	-	363	WP_001748026.1	Arm DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9356.66 Da
• Isoelectric Point: 5.6373

>T238483 WP_000994221.1 NZ_CP093402:3836553-3836810 [Salmonella enterica subsp. enterica serovar Agona]
MNASGVSVRHINSETCITTCYSQIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADGNEVQKLCEQLYQAERVVKGL
KDVLV

Nucleotide

• Length: 258 bp

>T238483 NZ_LR890361:69293-69775 [Klebsiella pneumoniae]
GTGGGACGTATAACCACGCCCGAGCCGTTATCCAGCTCTCATCAGCTGGCTGAGTTCGTCAGTGGAGAGACAGTCCTCGA
TGAATGGCTAAAACAGAGAGGTTTAAAAAATCAAGCTCTTGGCGCTGCCCGAACGTTCGTTGTTTGCAAGACGGGTACGA
AGCAAGTAGCTGGTTTTTACTCTTTGGCCACCGGTAGCGTTAACCATACGGAAGCGACAGGTAGTCTTCGGCGTAACATG
CCAGATCCTATACCGGTGATTATACTCGCTCGCCTGGCGGTAGATGTCTCATTGCACGGAAAAGGGGTTGGCGCCGATTT
ACTCCACGATGCAGTTCTACGGTGTTATCGCGTAGCTGAGAACATTGGGGTTCGTGCGATAATGGTTCATGCGCTTACTG
AAGAAGCCAAAGGTTTCTATGCTCACCATGGATTTAAGGCATCACAAACTCATGAGAGGACTCTGTTTCTAAAGCTTCCA
TGA

Antitoxin

Nucleotide

• Length: 379 bp

>AT238483 NZ_CP093402:c3836774-3836396 [Salmonella enterica subsp. enterica serovar Agona]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCCTGTGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAG
TAACAGGTGGTTATACAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAA
TTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCC
CCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3L1ZDZ2

Antitoxin