Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4030027..4030577 Replicon chromosome
Accession NZ_CP093392
Organism Salmonella enterica strain P201982

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag MOV21_RS19910 Protein ID WP_001199743.1
Coordinates 4030027..4030335 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag MOV21_RS19915 Protein ID WP_000016244.1
Coordinates 4030338..4030577 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV21_RS19900 (4025431) 4025431..4028946 - 3516 WP_238727947.1 AAA domain-containing protein -
MOV21_RS19905 (4029308) 4029308..4029592 - 285 Protein_3900 Arm DNA-binding domain-containing protein -
MOV21_RS19910 (4030027) 4030027..4030335 - 309 WP_001199743.1 CcdB family protein Toxin
MOV21_RS19915 (4030338) 4030338..4030577 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
MOV21_RS19920 (4030690) 4030690..4030938 - 249 WP_020898324.1 ribbon-helix-helix protein, CopG family -
MOV21_RS19925 (4031003) 4031003..4031836 - 834 WP_193432508.1 DUF4942 domain-containing protein -
MOV21_RS19930 (4031977) 4031977..4032599 - 623 Protein_3905 metallophosphoesterase -
MOV21_RS19935 (4032641) 4032641..4032994 - 354 WP_001181796.1 TA system toxin CbtA family protein -
MOV21_RS19940 (4033009) 4033009..4033337 - 329 Protein_3907 type IV toxin-antitoxin system YeeU family antitoxin -
MOV21_RS19945 (4033361) 4033361..4033582 - 222 WP_000691987.1 DUF987 family protein -
MOV21_RS19950 (4033579) 4033579..4034079 - 501 WP_000100794.1 DNA repair protein RadC -
MOV21_RS19955 (4034098) 4034098..4034919 - 822 WP_000197551.1 DUF932 domain-containing protein -
MOV21_RS19960 (4035003) 4035003..4035365 - 363 WP_000393539.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4017336..4046283 28947


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T238430 WP_001199743.1 NZ_CP093392:c4030335-4030027 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T238430 NZ_LR890343:640887-640990 [Klebsiella pneumoniae]
GCAAGGCGGCTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT238430 WP_000016244.1 NZ_CP093392:c4030577-4030338 [Salmonella enterica]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT238430 NZ_LR890343:c640997-640851 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAA
GTTGGCATTAATGCAGGCTAAGCCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References