Detailed information of TA system TA238414

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HigB-HigA
• Location: 4522956..4523710
• Replicon: chromosome
• Accession: NZ_CP093391
• Organism: Salmonella enterica strain P287611

Toxin (Protein)

• Gene name: higB
• Uniprot ID: B5F003
• Locus tag: MOV20_RS22200
• Protein ID: WP_000558166.1
• Coordinates: 4522956..4523267 (+)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: -
• Locus tag: MOV20_RS22205
• Protein ID: WP_001259011.1
• Coordinates: 4523264..4523710 (+)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOV20_RS22170 (4518622)	4518622..4519524	+	903	WP_000331364.1	formate dehydrogenase subunit beta	-
MOV20_RS22175 (4519521)	4519521..4520156	+	636	WP_000829025.1	formate dehydrogenase cytochrome b556 subunit	-
MOV20_RS22180 (4520153)	4520153..4521082	+	930	WP_000027734.1	formate dehydrogenase accessory protein FdhE	-
MOV20_RS22185 (4521120)	4521120..4521494	-	375	WP_000238494.1	type II toxin-antitoxin system VapC family toxin	-
MOV20_RS22190 (4521494)	4521494..4521736	-	243	WP_001523745.1	CopG family transcriptional regulator	-
MOV20_RS22195 (4521941)	4521941..4522870	+	930	WP_058661473.1	alpha/beta hydrolase	-
MOV20_RS22200 (4522956)	4522956..4523267	+	312	WP_000558166.1	type II toxin-antitoxin system HigB family toxin	Toxin
MOV20_RS22205 (4523264)	4523264..4523710	+	447	WP_001259011.1	type II toxin-antitoxin system HigA family antitoxin	Antitoxin
MOV20_RS22210 (4523725)	4523725..4524666	-	942	WP_238727967.1	fatty acid biosynthesis protein FabY	-
MOV20_RS22215 (4524711)	4524711..4525148	-	438	WP_000560956.1	D-aminoacyl-tRNA deacylase	-
MOV20_RS22220 (4525145)	4525145..4526017	-	873	WP_000921423.1	virulence factor BrkB family protein	-
MOV20_RS22225 (4526011)	4526011..4526610	-	600	WP_000965695.1	glucose-1-phosphatase	-
MOV20_RS22230 (4526801)	4526801..4527604	-	804	WP_000059693.1	DeoR/GlpR family DNA-binding transcription regulator	-
MOV20_RS22235 (4527638)	4527638..4528534	-	897	WP_001637558.1	sugar kinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, mRNA interferase HigB (21-93)

Antitoxin

• Cro/C1-type helix-turn-helix domain (93-146)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12432.40 Da
• Isoelectric Point: 9.5334

>T238414 WP_000558166.1 NZ_CP093391:4522956-4523267 [Salmonella enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Nucleotide

• Length: 312 bp

>T238414 NZ_LR890334:3945559-3945909 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16734.08 Da
• Isoelectric Point: 6.6451

>AT238414 WP_001259011.1 NZ_CP093391:4523264-4523710 [Salmonella enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Nucleotide

• Length: 447 bp

>AT238414 NZ_LR890334:3945314-3945565 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Structures

Toxin

• AlphaFold DB: A0A0R9ME90