Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4098003..4098519 Replicon chromosome
Accession NZ_CP093391
Organism Salmonella enterica strain P287611

Toxin (Protein)


Gene name relE Uniprot ID A0A2T8TGU4
Locus tag MOV20_RS20230 Protein ID WP_000220576.1
Coordinates 4098003..4098287 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag MOV20_RS20235 Protein ID WP_000212724.1
Coordinates 4098277..4098519 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV20_RS20215 (4093121) 4093121..4094773 + 1653 WP_000155063.1 alpha,alpha-phosphotrehalase -
MOV20_RS20220 (4095182) 4095182..4097320 + 2139 WP_086126515.1 anaerobic ribonucleoside-triphosphate reductase -
MOV20_RS20225 (4097535) 4097535..4097999 + 465 WP_001009177.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MOV20_RS20230 (4098003) 4098003..4098287 - 285 WP_000220576.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOV20_RS20235 (4098277) 4098277..4098519 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MOV20_RS20240 (4098597) 4098597..4100509 - 1913 Protein_3965 BglG family transcription antiterminator -
MOV20_RS20245 (4100526) 4100526..4101266 - 741 WP_000779265.1 KDGP aldolase family protein -
MOV20_RS20250 (4101263) 4101263..4102381 - 1119 WP_001139180.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MOV20_RS20255 (4102365) 4102365..4103498 - 1134 WP_000459931.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10855.65 Da        Isoelectric Point: 9.8739

>T238410 WP_000220576.1 NZ_CP093391:c4098287-4098003 [Salmonella enterica]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLDPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T238410 NZ_LR890334:c3116897-3116712 [Escherichia coli]
GTGAAAAGTGCAGACGTGATCGCCATCCTGAAGCAGCATGGCTGGGAACATATTCGAACCCGTGGCAGTCATCATCAGTT
CCGCCACCCTGTTCATCCGGGTCTGGTGACGGTTCCGCACCCTAAAAAAGATATTAAGCCCGGTACGCTGGCGCAAATTG
GGCGTCAGGCTGGTTTAACATTTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT238410 WP_000212724.1 NZ_CP093391:c4098519-4098277 [Salmonella enterica]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT238410 NZ_LR890334:c3116695-3116285 [Escherichia coli]
ATGTTTTATCCCGCCTATATCCACAGTGATCCTGACGGCAGCGCCAGCGGTTTTTTCCCTGATGTTCCAGGCTGTTATTT
TGCTGGTGATACGCTGGACAACGCTTTCCAGGATGCGCGAAGTGCACTGGCCGCGCACTTCGAAACCTTATGCGAGATGG
ATGAAGAGTTGCCGCTTCCAGGCTCTGTGGAAACACATCTGGTCCAGCGTGCGCAGGACTTTATTGGCGGGCAATGGTTG
CTGGTGGATATCAATATGAATCAGTTCGAAGGTCGGGCTGAACGTATCAATATTACGATGCCGAAAAGGTTACTGAACAA
GATTGATACCTACGTGCGCAATAACCCAGACTACGCCAACAGAAGTGCGTTTCTGGCAGAAGCTGCCCGGCGTGTATTGC
CGGGCGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8TGU4

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References