Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4040314..4040864 Replicon chromosome
Accession NZ_CP093391
Organism Salmonella enterica strain P287611

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag MOV20_RS19945 Protein ID WP_001199743.1
Coordinates 4040314..4040622 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag MOV20_RS19950 Protein ID WP_000016244.1
Coordinates 4040625..4040864 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV20_RS19935 (4035718) 4035718..4039233 - 3516 WP_238727947.1 AAA domain-containing protein -
MOV20_RS19940 (4039595) 4039595..4039879 - 285 Protein_3907 Arm DNA-binding domain-containing protein -
MOV20_RS19945 (4040314) 4040314..4040622 - 309 WP_001199743.1 CcdB family protein Toxin
MOV20_RS19950 (4040625) 4040625..4040864 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
MOV20_RS19955 (4040977) 4040977..4041225 - 249 WP_020898324.1 ribbon-helix-helix protein, CopG family -
MOV20_RS19960 (4041290) 4041290..4042123 - 834 WP_193432508.1 DUF4942 domain-containing protein -
MOV20_RS19965 (4042264) 4042264..4042886 - 623 Protein_3912 metallophosphoesterase -
MOV20_RS19970 (4042928) 4042928..4043281 - 354 WP_001181796.1 TA system toxin CbtA family protein -
MOV20_RS19975 (4043296) 4043296..4043624 - 329 Protein_3914 type IV toxin-antitoxin system YeeU family antitoxin -
MOV20_RS19980 (4043648) 4043648..4043869 - 222 WP_000691987.1 DUF987 family protein -
MOV20_RS19985 (4043866) 4043866..4044366 - 501 WP_000100794.1 DNA repair protein RadC -
MOV20_RS19990 (4044385) 4044385..4045206 - 822 WP_000197551.1 DUF932 domain-containing protein -
MOV20_RS19995 (4045290) 4045290..4045652 - 363 WP_000393539.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4027623..4056571 28948


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T238409 WP_001199743.1 NZ_CP093391:c4040622-4040314 [Salmonella enterica]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

>T238409 NZ_LR890334:c3060051-3059944 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT238409 WP_000016244.1 NZ_CP093391:c4040864-4040625 [Salmonella enterica]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp

>AT238409 NZ_LR890334:3060099-3060165 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References