Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3440117..3440737 Replicon chromosome
Accession NZ_CP093391
Organism Salmonella enterica strain P287611

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MOV20_RS17180 Protein ID WP_001280991.1
Coordinates 3440519..3440737 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MOV20_RS17175 Protein ID WP_000344807.1
Coordinates 3440117..3440491 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV20_RS17165 (3435256) 3435256..3436449 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MOV20_RS17170 (3436472) 3436472..3439621 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MOV20_RS17175 (3440117) 3440117..3440491 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MOV20_RS17180 (3440519) 3440519..3440737 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MOV20_RS17185 (3440917) 3440917..3441468 + 552 WP_001278792.1 maltose O-acetyltransferase -
MOV20_RS17190 (3441586) 3441586..3442056 + 471 WP_000136183.1 YlaC family protein -
MOV20_RS17195 (3442111) 3442111..3442251 - 141 WP_001197748.1 type B 50S ribosomal protein L36 -
MOV20_RS17200 (3442257) 3442257..3442517 - 261 WP_000801421.1 type B 50S ribosomal protein L31 -
MOV20_RS17205 (3442742) 3442742..3444292 + 1551 WP_000213153.1 EAL domain-containing protein -
MOV20_RS17215 (3444523) 3444523..3444912 + 390 WP_000961283.1 MGMT family protein -
MOV20_RS17220 (3444945) 3444945..3445514 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T238408 WP_001280991.1 NZ_CP093391:3440519-3440737 [Salmonella enterica]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T238408 NZ_LR890334:c3059569-3059462 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT238408 WP_000344807.1 NZ_CP093391:3440117-3440491 [Salmonella enterica]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT238408 NZ_LR890334:3059617-3059683 [Escherichia coli]
GGTCTAGATGCAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References