Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 2121475..2122037 Replicon chromosome
Accession NZ_CP093391
Organism Salmonella enterica strain P287611

Toxin (Protein)


Gene name higB Uniprot ID A0A5U2RHV4
Locus tag MOV20_RS10675 Protein ID WP_071686223.1
Coordinates 2121759..2122037 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag MOV20_RS10670 Protein ID WP_001240607.1
Coordinates 2121475..2121759 (-) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOV20_RS10645 (2117143) 2117143..2117865 - 723 WP_048591017.1 SPI-1 type III secretion system guanine nucleotide exchange factor SopE -
MOV20_RS10650 (2118075) 2118075..2118283 + 209 Protein_2090 helix-turn-helix domain-containing protein -
MOV20_RS10655 (2118415) 2118415..2119116 - 702 WP_086126161.1 DUF1076 domain-containing protein -
MOV20_RS10660 (2119940) 2119940..2120335 - 396 Protein_2092 tyrosine-type recombinase/integrase -
MOV20_RS10665 (2120978) 2120978..2121316 + 339 WP_114050305.1 T3SS effector NleG family protein -
MOV20_RS10670 (2121475) 2121475..2121759 - 285 WP_001240607.1 HigA family addiction module antitoxin Antitoxin
MOV20_RS10675 (2121759) 2121759..2122037 - 279 WP_071686223.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MOV20_RS10680 (2122289) 2122289..2122549 + 261 WP_002953402.1 hypothetical protein -
MOV20_RS10685 (2122620) 2122620..2123303 - 684 WP_238728147.1 PipA/GogA/GtgA family type III secretion system effector -
MOV20_RS10690 (2123822) 2123822..2124280 + 459 WP_000502123.1 IS200/IS605-like element IS200F family transposase -
MOV20_RS10695 (2124440) 2124440..2125270 + 831 WP_227012499.1 hypothetical protein -
MOV20_RS10700 (2125273) 2125273..2125804 + 532 Protein_2100 tail fiber assembly protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - sseI/srfH / sspH1 / sopE2 / sspH2 / sspH1 / sspH2 2000237..2140720 140483
- flank IS/Tn - - 2124035..2124280 245


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10751.24 Da        Isoelectric Point: 9.4011

>T238407 WP_071686223.1 NZ_CP093391:c2122037-2121759 [Salmonella enterica]
MIKSFRHKGLKKFYQKGDSSGLEQSLVPRLKNRLSMLDAAKTIDFLNQQGYDLHELKGDRAETWSIKVSGNWRLTFIFEN
GDVYVLNLEDYH

Download         Length: 279 bp

>T238407 NZ_LR890334:c3059085-3058978 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTCTGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10187.74 Da        Isoelectric Point: 5.6051

>AT238407 WP_001240607.1 NZ_CP093391:c2121759-2121475 [Salmonella enterica]
MAMFDPAYPGEIIAEILEDQGVSLRQFAVAMNIAPSTASRILSGKVSITPEMAVKLAIVLGGDAESWLNLQNNYSLSQAR
KTVDITHVHRLSFA

Download         Length: 285 bp

>AT238407 NZ_LR890334:3059142-3059197 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5U2RHV4

Antitoxin

Source ID Structure

References