Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4338791..4339572 Replicon chromosome
Accession NZ_CP093386
Organism Salmonella enterica strain P048595

Toxin (Protein)


Gene name TacT2 Uniprot ID E8X9W8
Locus tag MOQ57_RS21185 Protein ID WP_000626099.1
Coordinates 4338791..4339282 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag MOQ57_RS21190 Protein ID WP_001110452.1
Coordinates 4339279..4339572 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MOQ57_RS21150 (4334786) 4334786..4335361 + 576 WP_001188509.1 transcriptional regulator -
MOQ57_RS21160 (4335632) 4335632..4335709 - 78 Protein_4139 helix-turn-helix domain-containing protein -
MOQ57_RS21165 (4335800) 4335800..4336132 - 333 WP_001165471.1 MerR family transcriptional regulator -
MOQ57_RS21170 (4336204) 4336204..4336581 + 378 WP_000916345.1 EthD family reductase -
MOQ57_RS21175 (4337614) 4337614..4337688 + 75 Protein_4142 porin family protein -
MOQ57_RS21180 (4337791) 4337791..4338543 + 753 WP_000842434.1 non-specific acid phosphatase -
MOQ57_RS21185 (4338791) 4338791..4339282 - 492 WP_000626099.1 GNAT family N-acetyltransferase Toxin
MOQ57_RS21190 (4339279) 4339279..4339572 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
MOQ57_RS21195 (4339889) 4339889..4340110 + 222 WP_001576552.1 hypothetical protein -
MOQ57_RS21200 (4340375) 4340375..4341250 + 876 WP_000921674.1 AraC family transcriptional regulator -
MOQ57_RS21205 (4341247) 4341247..4341534 + 288 WP_001269916.1 transcriptional regulator RtsB -
MOQ57_RS21210 (4341557) 4341557..4341772 + 216 WP_001595136.1 hypothetical protein -
MOQ57_RS21215 (4341780) 4341780..4342049 + 270 WP_010989096.1 hypothetical protein -
MOQ57_RS21220 (4342343) 4342343..4343248 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17646.39 Da        Isoelectric Point: 6.8437

>T238369 WP_000626099.1 NZ_CP093386:c4339282-4338791 [Salmonella enterica]
MISTPEPLHAGHILTPFCCGVDSIDNWLEQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T238369 NZ_LR890326:285427-285600 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGCGCATTCCTGGTCGGAATAACCTGGCCAATGAGTTTACCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT238369 WP_001110452.1 NZ_CP093386:c4339572-4339279 [Salmonella enterica]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT238369 NZ_LR890326:285103-285399 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACCGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7AK7

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References