Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4415951..4416608 Replicon chromosome
Accession NC_012731
Organism Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag KP1_RS21520 Protein ID WP_002916310.1
Coordinates 4415951..4416361 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag KP1_RS21525 Protein ID WP_002916312.1
Coordinates 4416342..4416608 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KP1_RS21500 4411951..4413684 - 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -
KP1_RS21505 4413690..4414403 - 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KP1_RS21510 4414426..4415322 - 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
KP1_RS21515 4415423..4415944 + 522 WP_002916308.1 flavodoxin FldB -
KP1_RS21520 4415951..4416361 - 411 WP_002916310.1 protein YgfX Toxin
KP1_RS21525 4416342..4416608 - 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
KP1_RS21530 4416854..4417837 + 984 WP_014906951.1 tRNA-modifying protein YgfZ -
KP1_RS21535 4417936..4418595 - 660 WP_002916317.1 hemolysin III family protein -
KP1_RS21540 4418759..4419070 - 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
KP1_RS21545 4419120..4419848 + 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
KP1_RS21550 4419967..4421400 + 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T23835 WP_002916310.1 NC_012731:c4416361-4415951 [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T23835 NC_012731:c4416361-4415951 [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAAATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT23835 WP_002916312.1 NC_012731:c4416608-4416342 [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT23835 NC_012731:c4416608-4416342 [Klebsiella pneumoniae subsp. pneumoniae NTUH-K2044]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References