Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 2467616..2468142 | Replicon | chromosome |
| Accession | NZ_CP093369 | ||
| Organism | Escherichia coli strain EV36 mutant 5a | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | L0Q35_RS11935 | Protein ID | WP_000323025.1 |
| Coordinates | 2467616..2467903 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | L0Q35_RS11940 | Protein ID | WP_000534858.1 |
| Coordinates | 2467903..2468142 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L0Q35_RS11885 (2462640) | 2462640..2462855 | - | 216 | WP_000839590.1 | phage lysis protein EssD | - |
| L0Q35_RS11890 (2463075) | 2463075..2463245 | + | 171 | WP_211180497.1 | putative zinc-binding protein YnfU | - |
| L0Q35_RS11895 (2463609) | 2463609..2463824 | - | 216 | WP_000066484.1 | cold shock-like protein CspB | - |
| L0Q35_RS11900 (2464125) | 2464125..2464337 | + | 213 | WP_000087756.1 | cold shock-like protein CspF | - |
| L0Q35_RS11905 (2464392) | 2464392..2464481 | + | 90 | WP_120795389.1 | hypothetical protein | - |
| L0Q35_RS11910 (2464759) | 2464759..2465511 | - | 753 | WP_001047135.1 | antitermination protein | - |
| L0Q35_RS11915 (2465525) | 2465525..2466574 | - | 1050 | WP_001393597.1 | DUF968 domain-containing protein | - |
| L0Q35_RS11920 (2466576) | 2466576..2466854 | - | 279 | WP_012304870.1 | hypothetical protein | - |
| L0Q35_RS11925 (2466921) | 2466921..2467172 | - | 252 | WP_000980994.1 | protein Rem | - |
| L0Q35_RS11930 (2467389) | 2467389..2467544 | - | 156 | WP_000813254.1 | type I toxin-antitoxin system toxin HokD | - |
| L0Q35_RS11935 (2467616) | 2467616..2467903 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| L0Q35_RS11940 (2467903) | 2467903..2468142 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| L0Q35_RS11945 (2468167) | 2468167..2468472 | + | 306 | WP_001326990.1 | protein YdfV | - |
| L0Q35_RS11950 (2468675) | 2468675..2469007 | + | 333 | WP_001301033.1 | FlxA-like family protein | - |
| L0Q35_RS11955 (2469444) | 2469444..2469593 | - | 150 | WP_011443592.1 | protein YdfW | - |
| L0Q35_RS11960 (2469628) | 2469628..2469906 | - | 279 | Protein_2350 | protein YdfX | - |
| L0Q35_RS11965 (2469890) | 2469890..2470120 | - | 231 | WP_000920568.1 | dicB transcriptional regulator DicC | - |
| L0Q35_RS11970 (2470204) | 2470204..2470611 | + | 408 | WP_000448564.1 | DNA-binding transcriptional dual regulator DicA | - |
| L0Q35_RS11975 (2470778) | 2470778..2470933 | + | 156 | WP_000379575.1 | DUF1391 family protein | - |
| L0Q35_RS22730 (2470935) | 2470935..2471063 | + | 129 | WP_000344964.1 | protein YdfB | - |
| L0Q35_RS11980 (2471093) | 2471093..2471311 | + | 219 | WP_001171942.1 | protein YdfC | - |
| L0Q35_RS11985 (2471879) | 2471879..2472067 | + | 189 | WP_000854559.1 | cell division inhibition protein DicB | - |
| L0Q35_RS11990 (2472064) | 2472064..2472255 | + | 192 | WP_001083297.1 | lysis protein YdfD | - |
| L0Q35_RS11995 (2472348) | 2472348..2473115 | + | 768 | Protein_2358 | exonuclease | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 2437074..2479014 | 41940 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T238280 WP_000323025.1 NZ_CP093369:c2467903-2467616 [Escherichia coli]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T238280 NZ_CP093369:c2467903-2467616 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT238280 WP_000534858.1 NZ_CP093369:c2468142-2467903 [Escherichia coli]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT238280 NZ_CP093369:c2468142-2467903 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|