Detailed information of TA system TA238234

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4686070..4687328
• Replicon: chromosome
• Accession: NZ_CP093358
• Organism: Pseudomonas aeruginosa strain E167

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: MN180_RS21975
• Protein ID: WP_023114076.1
• Coordinates: 4686070..4686825 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: MN180_RS21980
• Protein ID: WP_003086329.1
• Coordinates: 4686960..4687328 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MN180_RS21965 (MN180_21965)	4681243..4683786	+	2544	WP_009315399.1	acyl-homoserine-lactone acylase QuiP	-
MN180_RS21970 (MN180_21970)	4683941..4685302	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
MN180_RS21975 (MN180_21975)	4686070..4686825	-	756	WP_023114076.1	RES family NAD+ phosphorylase	Toxin
MN180_RS21980 (MN180_21980)	4686960..4687328	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
MN180_RS21985 (MN180_21985)	4687401..4688687	-	1287	WP_003449000.1	FAD-binding oxidoreductase	-
MN180_RS21990 (MN180_21990)	4688743..4690236	-	1494	WP_023114075.1	aldehyde dehydrogenase family protein	-
MN180_RS21995 (MN180_21995)	4690411..4690887	+	477	WP_003134036.1	elongation factor GreAB	-
MN180_RS22000 (MN180_22000)	4690890..4691165	-	276	WP_023088486.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28309.54 Da
• Isoelectric Point: 8.3428

>T238234 WP_023114076.1 NZ_CP093358:c4686825-4686070 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGMRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWKL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T238234 NZ_LR890286:781276-781686 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT238234 WP_003086329.1 NZ_CP093358:c4687328-4686960 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT238234 NZ_LR890286:781029-781295 [Klebsiella pneumoniae]
ATGGACATTAACAATAAAGCACGTATCCACTGGGCATGCCGCCGCGGGATGCGCGAACTCGACATCTCCATCATGCCGTT
CTTTGAGTATGAGTACGATACCCTCAGCGACGCTGACAAACAGCTGTTCATTCGCCTGCTGGAAAATGACGATCCGGATC
TGTTCAACTGGCTGATGAACCACGGCAAACCGGCCGATGCGGAGCTGCAGCGGATGGTAACCTTAATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Antitoxin

• AlphaFold DB: V6AJU7