Detailed information of TA system TA238161

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): higBA (relBE)/HTH(antitoxin)
• Location: 2263758..2264363
• Replicon: chromosome
• Accession: NZ_CP093332
• Organism: Buttiauxella ferragutiae strain H4-C11

Toxin (Protein)

• Gene name: higB
• Uniprot ID: -
• Locus tag: MNO13_RS10420
• Protein ID: WP_241939953.1
• Coordinates: 2264052..2264363 (-)
• Length: 104 a.a.

Antitoxin (Protein)

• Gene name: higA
• Uniprot ID: A0A4R6E9Q1
• Locus tag: MNO13_RS10415
• Protein ID: WP_064545757.1
• Coordinates: 2263758..2264051 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNO13_RS10395 (MNO13_10395)	2260008..2260961	+	954	WP_064545752.1	ABC transporter permease	-
MNO13_RS10400 (MNO13_10400)	2260966..2261811	+	846	WP_121813736.1	ABC transporter permease	-
MNO13_RS10405 (MNO13_10405)	2261804..2262787	+	984	WP_241939952.1	ABC transporter ATP-binding protein	-
MNO13_RS10410 (MNO13_10410)	2262774..2263751	+	978	WP_064545756.1	ABC transporter ATP-binding protein	-
MNO13_RS10415 (MNO13_10415)	2263758..2264051	-	294	WP_064545757.1	NadS family protein	Antitoxin
MNO13_RS10420 (MNO13_10420)	2264052..2264363	-	312	WP_241939953.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MNO13_RS10425 (MNO13_10425)	2264572..2264823	+	252	WP_034496127.1	DUF2766 family protein	-
MNO13_RS10430 (MNO13_10430)	2264864..2266207	-	1344	WP_064545758.1	anaerobic C4-dicarboxylate transporter	-
MNO13_RS10435 (MNO13_10435)	2266356..2268374	-	2019	WP_064545760.1	heparinase II/III family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-88)

Sequences

Toxin

Protein

• Length: 104 a.a.
• Molecular weight: 12168.10 Da
• Isoelectric Point: 9.5093

>T238161 WP_241939953.1 NZ_CP093332:c2264363-2264052 [Buttiauxella ferragutiae]
MLFIETPIFTEDVNALLTDEEYRLFQVFLTFSPESGDVIPHTGGLRKVRWPAKNKGKRSGVRVIYFHKNVDSIIRLLLIY
PKGVKDELDEAEKRFLRQMNERW

Nucleotide

• Length: 312 bp

>T238161 NZ_LR890240:c4572566-4572033 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCAGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10757.31 Da
• Isoelectric Point: 10.1757

>AT238161 WP_064545757.1 NZ_CP093332:c2264051-2263758 [Buttiauxella ferragutiae]
MDKQLFARLSESMTQMNEIVEGKREPSRATEVTATQVKTIRQATGLSQAGFARLISVSVDTLKNWEQGRREPTGPAKALL
RAIENDPEHVILALAPR

Nucleotide

• Length: 294 bp

>AT238161 NZ_LR890240:c4572843-4572577 [Klebsiella pneumoniae]
ATGCCCGCACTTAAAAAGCAGCGTATAGATTTGAGATTAACCGATGATGATAAGAGCATCATCGAGGAAGCTGCGGCAAT
TTCGAATCAGACGATTACCCAGTTTGTGGTTGCCAGTGCCTCAGAACGTGCTGCGGAAGTGATTGAGCAGCACCGCAGAA
TGGTCCTCAATGAGCAATCATGGAGCCTGGTGATGGAGGCGATTACCCAACCGCCAGCCCCGAATGATCGACTGAAACGT
GCAGCGAAGCGTCTACAAACCAGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A4R6E9Q1