Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 4451713..4452416 Replicon chromosome
Accession NZ_CP093314
Organism Klebsiella pneumoniae strain HUM7199

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag MLA24_RS21780 Protein ID WP_263852637.1
Coordinates 4451713..4452054 (-) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID A0A939NIK9
Locus tag MLA24_RS21785 Protein ID WP_032434296.1
Coordinates 4452075..4452416 (-) Length 114 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MLA24_RS21770 (4448028) 4448028..4448897 + 870 WP_023317468.1 HNH endonuclease -
MLA24_RS21775 (4449488) 4449488..4451521 + 2034 WP_050598589.1 hypothetical protein -
MLA24_RS21780 (4451713) 4451713..4452054 - 342 WP_263852637.1 toxin Toxin
MLA24_RS21785 (4452075) 4452075..4452416 - 342 WP_032434296.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
MLA24_RS21790 (4452427) 4452427..4452969 - 543 WP_032434298.1 DNA repair protein RadC -
MLA24_RS21795 (4452982) 4452982..4453422 - 441 WP_032434300.1 antirestriction protein -
MLA24_RS21800 (4453453) 4453453..4454274 - 822 WP_032434301.1 DUF932 domain-containing protein -
MLA24_RS21805 (4454394) 4454394..4454867 - 474 WP_032434303.1 hypothetical protein -
MLA24_RS21810 (4454939) 4454939..4455391 - 453 WP_032410767.1 hypothetical protein -
MLA24_RS21815 (4455427) 4455427..4456143 - 717 WP_032434305.1 WYL domain-containing protein -
MLA24_RS21820 (4456387) 4456387..4457261 - 875 Protein_4274 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4440010..4484850 44840


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(13-112)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12828.85 Da        Isoelectric Point: 9.5459

>T238063 WP_263852637.1 NZ_CP093314:c4452054-4451713 [Klebsiella pneumoniae]
MKTLPATTPQAVTLCLSSVAVWQMLLARLLEQHYGLTLNDTPFSDETVIQEHIDAGISLADAVNFLVEKYGLVIFYRKGF
NWQEHSPYLRAVDILRARQATGLLRRSRKNAVR

Download         Length: 342 bp

>T238063 NZ_LR890198:c4580374-4580201 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 114 a.a.        Molecular weight: 12893.40 Da        Isoelectric Point: 5.9612

>AT238063 WP_032434296.1 NZ_CP093314:c4452416-4452075 [Klebsiella pneumoniae]
MKSTDSENDSFLKWGLNRNVTPCFGARLVQEGNRLHYLADRASITGEFSNAESLKLDEVFPHFISQMESMLTTGEMNPRH
AHFFTLYHNGFTCEADTLGSYGYVYIAVYPTQR

Download         Length: 342 bp

>AT238063 NZ_LR890198:c4580698-4580402 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References