Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 797068..797900 | Replicon | chromosome |
| Accession | NZ_CP093283 | ||
| Organism | Escherichia coli strain EC-14-2-9 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A7ZVJ9 |
| Locus tag | MNY25_RS03880 | Protein ID | WP_000854765.1 |
| Coordinates | 797068..797442 (-) | Length | 125 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | S1NM52 |
| Locus tag | MNY25_RS03885 | Protein ID | WP_001295723.1 |
| Coordinates | 797532..797900 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MNY25_RS03845 (792146) | 792146..792745 | + | 600 | WP_001255034.1 | type II secretion system minor pseudopilin GspJ | - |
| MNY25_RS03850 (792748) | 792748..793725 | + | 978 | WP_000633209.1 | type II secretion system minor pseudopilin GspK | - |
| MNY25_RS03855 (793722) | 793722..794900 | + | 1179 | WP_000094991.1 | type II secretion system protein GspL | - |
| MNY25_RS03860 (794902) | 794902..795438 | + | 537 | WP_000942785.1 | GspM family type II secretion system protein YghD | - |
| MNY25_RS03865 (795719) | 795719..796561 | - | 843 | WP_022645115.1 | DUF4942 domain-containing protein | - |
| MNY25_RS03870 (796646) | 796646..796840 | - | 195 | WP_024181941.1 | DUF957 domain-containing protein | - |
| MNY25_RS03875 (796865) | 796865..797068 | - | 204 | WP_221924765.1 | DUF5983 family protein | - |
| MNY25_RS03880 (797068) | 797068..797442 | - | 375 | WP_000854765.1 | TA system toxin CbtA family protein | Toxin |
| MNY25_RS03885 (797532) | 797532..797900 | - | 369 | WP_001295723.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| MNY25_RS03890 (798063) | 798063..798284 | - | 222 | WP_000692341.1 | DUF987 domain-containing protein | - |
| MNY25_RS03895 (798347) | 798347..798823 | - | 477 | WP_001186774.1 | RadC family protein | - |
| MNY25_RS03900 (798839) | 798839..799318 | - | 480 | WP_057109541.1 | antirestriction protein | - |
| MNY25_RS03905 (799584) | 799584..800402 | - | 819 | WP_001175165.1 | DUF932 domain-containing protein | - |
| MNY25_RS03910 (800492) | 800492..800725 | - | 234 | WP_001278293.1 | DUF905 family protein | - |
| MNY25_RS03915 (800731) | 800731..801408 | - | 678 | WP_001097302.1 | hypothetical protein | - |
| MNY25_RS03920 (801556) | 801556..802236 | - | 681 | WP_001282921.1 | WYL domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | sul2 / aph(3'')-Ib / aph(6)-Id / tet(A) / floR | rfaE / gspC / gspD / gspE / gspE / gspF / gspG / gspH / gspI / gspJ / gspK / gspL / gspM / papI | 687767..893129 | 205362 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 125 a.a. Molecular weight: 13970.98 Da Isoelectric Point: 7.2909
>T237996 WP_000854765.1 NZ_CP093283:c797442-797068 [Escherichia coli]
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
MKTLPDTHVREVSCCPSPVTIWQTLLTRLLDQHYSLTLNDTPFVDERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGASSQLINSIDILRARRATGLMTRHNYRTVNNITLGKYPEAK
Download Length: 375 bp
>T237996 NZ_LR883965:4311205-4311603 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13592.40 Da Isoelectric Point: 6.6255
>AT237996 WP_001295723.1 NZ_CP093283:c797900-797532 [Escherichia coli]
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDTLSGTTHPDDNDDHPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFRDADAYPLDQAFPLLMKQLKLMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT237996 NZ_LR883965:4310978-4311205 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|