Detailed information of TA system TA237907

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2337527..2339115
• Replicon: chromosome
• Accession: NZ_CP093239
• Organism: Escherichia marmotae strain W49-2

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: MNY74_RS11065
• Protein ID: WP_105224335.1
• Coordinates: 2337793..2339115 (+)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: MNY74_RS11060
• Protein ID: WP_001516368.1
• Coordinates: 2337527..2337793 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNY74_RS11045 (2334203)	2334203..2335117	+	915	WP_001516366.1	bestrophin family protein	-
MNY74_RS11050 (2335121)	2335121..2335879	-	759	WP_061090837.1	trans-aconitate 2-methyltransferase	-
MNY74_RS11055 (2336307)	2336307..2337263	+	957	WP_000197006.1	hypothetical protein	-
MNY74_RS11060 (2337527)	2337527..2337793	+	267	WP_001516368.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
MNY74_RS11065 (2337793)	2337793..2339115	+	1323	WP_105224335.1	type II toxin-antitoxin system serine/threonine protein kinase toxin HipA	Toxin
MNY74_RS11070 (2339429)	2339429..2340214	-	786	WP_241556836.1	hypothetical protein	-
MNY74_RS11075 (2340265)	2340265..2341971	-	1707	WP_170897941.1	major capsid protein	-
MNY74_RS11080 (2342117)	2342117..2342629	-	513	WP_241556837.1	hypothetical protein	-
MNY74_RS11085 (2342610)	2342610..2342879	-	270	WP_241556838.1	hypothetical protein	-
MNY74_RS11090 (2342866)	2342866..2343729	-	864	WP_212768122.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2336307..2355954	19647

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (149-402)

Antitoxin

• Cro/C1-type helix-turn-helix domain (18-69)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49586.23 Da
• Isoelectric Point: 8.5841

>T237907 WP_105224335.1 NZ_CP093239:2337793-2339115 [Escherichia marmotae]
MPKLVTWMNNQRVGELTKLTNGAHTFKYAPEWLTNRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPEDETVTRPIMVWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRMGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKEFGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGSTDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGRKTEIDKIYPRHFLATAKALKFPEVQMHEILSDFARMIP
AALDNVKASLPADFPENVLTAIETNVLRLHGRLSREYGIK

Nucleotide

• Length: 1323 bp

>T237907 NZ_LR883006:904263-904670 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGCTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATAGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10034.37 Da
• Isoelectric Point: 4.5668

>AT237907 WP_001516368.1 NZ_CP093239:2337527-2337793 [Escherichia marmotae]
MMSFPMIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLNLSMTLCDTKNDSPES
TDQQDLEW

Nucleotide

• Length: 267 bp

>AT237907 NZ_LR883006:904016-904282 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA