Detailed information of TA system TA237815

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-ralA/-
• Location: 2645..3066
• Replicon: chromosome
• Accession: NZ_CP093221
• Organism: Escherichia coli strain ER2683

Toxin (Protein)

• Gene name: hok
• Uniprot ID: -
• Locus tag: MNV48_RS00030
• Protein ID: WP_096937776.1
• Coordinates: 2645..2770 (-)
• Length: 42 a.a.

Antitoxin (RNA)

Gene name	ralA
Locus tag	-
Coordinates	2868..3066 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNV48_RS00010 (520)	520..1341	-	822	WP_001234417.1	DUF932 domain-containing protein	-
MNV48_RS00015 (1460)	1460..1747	-	288	WP_000107542.1	hypothetical protein	-
MNV48_RS00020 (1772)	1772..1978	-	207	WP_000547965.1	hypothetical protein	-
MNV48_RS00025 (2048)	2048..2344	+	297	Protein_4	hypothetical protein	-
MNV48_RS00030 (2645)	2645..2770	-	126	WP_096937776.1	type I toxin-antitoxin system Hok family toxin	Toxin
MNV48_RS00035 (2712)	2712..2861	-	150	Protein_6	DUF5431 family protein	-
- (2868)	2868..3066	-	199	NuclAT_1	-	Antitoxin
- (2868)	2868..3066	-	199	NuclAT_1	-	Antitoxin
- (2868)	2868..3066	-	199	NuclAT_1	-	Antitoxin
- (2868)	2868..3066	-	199	NuclAT_1	-	Antitoxin
MNV48_RS00040 (3035)	3035..3797	-	763	Protein_7	plasmid SOS inhibition protein A	-
MNV48_RS00045 (3794)	3794..4228	-	435	WP_000845928.1	conjugation system SOS inhibitor PsiB	-
MNV48_RS00050 (4283)	4283..6241	-	1959	WP_000117173.1	ParB/RepB/Spo0J family partition protein	-
MNV48_RS00055 (6307)	6307..6540	-	234	WP_000005990.1	DUF905 family protein	-
MNV48_RS00060 (6597)	6597..7136	-	540	WP_000290801.1	single-stranded DNA-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (2-37)

Sequences

Toxin

Protein

• Length: 42 a.a.
• Molecular weight: 4806.72 Da
• Isoelectric Point: 8.4890

>T237815 WP_096937776.1 NZ_CP093221:c2770-2645 [Escherichia coli]
VLIVCLTLLIFTYLTRKSLCEIRYRDGYREVAAFMAYESGK

Nucleotide

• Length: 126 bp

>T237815 NZ_LR882967:5055007-5055267 [Planktothrix pseudagardhii]
ATGAGCCTTAACAATAAACAGCGTCGAACGTTAGAATTAATTTTTACTGATCCTATTCCGACAACGATTAATTGGCAAGA
TATTGAAAATTTATTCCAAGCGTTAGGAGCAACTATTATGCAAGGTAGAGGTTCAAGAATTCGGGTTTTACTCAACAATG
TTAGAGCTATTTTTCATCAACCCCATCCTCAGAAGGAAACAGATAGAGGAGCGGTCAAATCAGTTAGAGAGTTTCTAATA
AAGGCAGGCGTTAAACCTTGA

Antitoxin

Nucleotide

• Length: 199 bp

>AT237815 NZ_CP093221:c3066-2868 [Escherichia coli]
TCACACAGATTACCCGTAAACAGCCTGAATGAGCGGGTTATTTTCAGGAAAAGTGAGTGTGGTCAGCGTGCAGGGATATG
GGCTATGATGTGCCCGGCGCTTGAGGCTTTCTGCCTCATGACGTGAAGGTGGTTTGTTGCCGTGTTGTGTGGCAGAAGGA
CAAAAGCCCCGTAGTTAATTTTTCATTAACCCACGAGGC

Structures

Antitoxin