Detailed information of TA system TA237591

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 142121..142626
• Replicon: chromosome
• Accession: NZ_CP093030
• Organism: Pseudomonas aeruginosa strain H04

Toxin (Protein)

• Gene name: parE
• Uniprot ID: V6A7K8
• Locus tag: MMZ67_RS00655
• Protein ID: WP_003083773.1
• Coordinates: 142121..142402 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A1C7BDS9
• Locus tag: MMZ67_RS00660
• Protein ID: WP_003083775.1
• Coordinates: 142399..142626 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ67_RS00630 (MMZ67_00630)	137372..138721	+	1350	WP_003119513.1	C4-dicarboxylate transporter DctA	-
MMZ67_RS00635 (MMZ67_00635)	138770..139456	+	687	WP_003083762.1	FadR/GntR family transcriptional regulator	-
MMZ67_RS00640 (MMZ67_00640)	139557..140291	+	735	WP_003117208.1	GntR family transcriptional regulator	-
MMZ67_RS00645 (MMZ67_00645)	140471..140881	+	411	WP_003110659.1	aegerolysin family protein	-
MMZ67_RS00650 (MMZ67_00650)	140913..141821	-	909	WP_003083769.1	LysR family transcriptional regulator	-
MMZ67_RS00655 (MMZ67_00655)	142121..142402	-	282	WP_003083773.1	type II toxin-antitoxin system toxin ParE	Toxin
MMZ67_RS00660 (MMZ67_00660)	142399..142626	-	228	WP_003083775.1	CopG family ribbon-helix-helix protein	Antitoxin
MMZ67_RS00665 (MMZ67_00665)	142802..143422	-	621	WP_031298866.1	hypothetical protein	-
MMZ67_RS00670 (MMZ67_00670)	143523..144023	+	501	WP_003101228.1	LEA type 2 family protein	-
MMZ67_RS00675 (MMZ67_00675)	144096..144437	+	342	WP_003101229.1	zinc ribbon domain-containing protein YjdM	-
MMZ67_RS00680 (MMZ67_00680)	144519..145946	-	1428	WP_023464187.1	GABA permease	-
MMZ67_RS00685 (MMZ67_00685)	146115..147608	-	1494	WP_016263977.1	CoA-acylating methylmalonate-semialdehyde dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-87)

Antitoxin

• Ribbon-helix-helix protein, CopG (5-42)

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10462.19 Da
• Isoelectric Point: 10.0435

>T237591 WP_003083773.1 NZ_CP093030:c142402-142121 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Nucleotide

• Length: 282 bp

>T237591 NZ_LR882497:c3712884-3712456 [Mycobacterium tuberculosis variant microti]
ATGCGAGCGCTGTTGGACGTCAACGTGCTACTGGCGCTGTTGGACCGCGATCACGTCGACCACGAGCGCGCCCGAGCGTG
GATCACCGGGCAGATCGAGCGGGGATGCGCTTCCTGTGCGATCACCCAAAACGGGTTCGTCCGCGTCATCAGCCAACCGC
GCTATCCCAGCCCAATCTCGGTAGCCCATGCCATCGACTTGTTGGCTCGTGCGACGCACACGCGCTATCACGAGTTCTGG
TCCTGCACCGTCAGCATTCTCGACTCAAAGGTCATCGATCGTTCCCGCCTGCACAGCCCCAAACAGGTCACCGACGCGTA
CTTGCTGGCCCTCGCGGTCGCTCATGATGGCCGATTTGTCACCTTCGATCAGTCGATTGCGTTGACTGCGGTTCCTGGCG
CAACCAAACAGCACCTGGCAACGCTGTAG

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8556.58 Da
• Isoelectric Point: 5.5740

>AT237591 WP_003083775.1 NZ_CP093030:c142626-142399 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Nucleotide

• Length: 228 bp

>AT237591 NZ_LR882497:c3713130-3712888 [Mycobacterium tuberculosis variant microti]
ATGCGCACCACGTTGTCCATCGACGACGATGTATTGCTGGCCGTGAAGGAACGGGCACGCAGGGAGAAGCGCACCGCGGG
TGAAATCCTGTCGGATCTGGCCCGGCAAGCGTTAACCAACCAGAATCCCCAGCCTGCGGCGAGCCAGGAGGACGCCTTTC
ATGGCTTCGAACCCCTGCCTCATCGCGGTGGAGCGGTATCGAACGCGCTGATCGATCGGCTTCGTGACGAGGAGGCCGTG
TGA

Structures

Toxin

• PDB: 6XRW

Antitoxin

• AlphaFold DB: A0A1C7BDS9