Detailed information of TA system TA237542

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4635905..4637163
• Replicon: chromosome
• Accession: NZ_CP093015
• Organism: Pseudomonas aeruginosa strain H16

Toxin (Protein)

• Gene name: -
• Uniprot ID: V6AJ34
• Locus tag: MMZ76_RS21440
• Protein ID: WP_003086331.1
• Coordinates: 4635905..4636660 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: MMZ76_RS21445
• Protein ID: WP_003086329.1
• Coordinates: 4636795..4637163 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MMZ76_RS21430 (MMZ76_21435)	4631076..4633619	+	2544	WP_009315399.1	acyl-homoserine-lactone acylase QuiP	-
MMZ76_RS21435 (MMZ76_21440)	4633774..4635135	-	1362	WP_003134034.1	DNA recombination protein RmuC	-
MMZ76_RS21440 (MMZ76_21445)	4635905..4636660	-	756	WP_003086331.1	RES family NAD+ phosphorylase	Toxin
MMZ76_RS21445 (MMZ76_21450)	4636795..4637163	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
MMZ76_RS21450 (MMZ76_21455)	4637236..4638522	-	1287	WP_034083319.1	FAD-binding oxidoreductase	-
MMZ76_RS21455 (MMZ76_21460)	4638578..4640167	-	1590	WP_022580156.1	aldehyde dehydrogenase family protein	-
MMZ76_RS21460 (MMZ76_21465)	4640245..4640721	+	477	WP_003086322.1	hypothetical protein	-
MMZ76_RS21465 (MMZ76_21470)	4640724..4640999	-	276	WP_023098713.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28236.34 Da
• Isoelectric Point: 7.7294

>T237542 WP_003086331.1 NZ_CP093015:c4636660-4635905 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T237542 NZ_LR882497:679393-679800 [Mycobacterium tuberculosis variant microti]
GTGATCATCGACACGAGTGCGCTGCTTGCCTATTTCGACGCCGCCGAGCCAGACCACGCCGCAGTGTCTGAGTGCATCGA
TAGCTCCGCAGACGCGCTCGTCGTATCCCCTTATGTGGTAGCGGAACTCGACTATCTCGTCGCCACCCGGGTAGGTGTCG
ATGCCGAGCTCGCCGTCCTGCGTGAACTCGCCGGCGGGGCCTGGGAGCTCGCCAACTGCGGTGCCGCCGAAATCGAGCAG
GCCGCCCGCATCGTCACGAAATACCAGGATCAGCGGATCGGGATCGCGGATGCGGCCAACGTCGTGCTGGCCGACCGATA
CCGCACGCGCACGATCCTCACCCTGGACCGTCGGCACTTCTCGGCGCTGCGGCCGATCGGCGGTGGGCGCTTCACCGTCA
TTCCGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT237542 WP_003086329.1 NZ_CP093015:c4637163-4636795 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT237542 NZ_LR882497:679181-679396 [Mycobacterium tuberculosis variant microti]
GTGGACAAGACGACGGTCTACCTGCCGGATGAACTCAAGGCGGCCGTGAAGCGCGCCGCTCGGCAGCGCGGAGTCTCCGA
AGCGCAGGTAATCCGGGAGTCCATCCGGGCGGCGGTCGGCGGCGCCAAGCCGCCGCCGCGCGGGGGTCTATATGCGGGTT
CGGAGCCCATCGCGCGGCGAGTCGACGAGCTGCTGGCTGGCTTCGGTGAGCGGTGA

Structures

Toxin

• AlphaFold DB: V6AJ34

Antitoxin

• AlphaFold DB: V6AJU7