Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143591..144096 Replicon chromosome
Accession NZ_CP093014
Organism Pseudomonas aeruginosa strain H17

Toxin (Protein)


Gene name parE Uniprot ID A0A069QL22
Locus tag MMZ77_RS00665 Protein ID WP_003121619.1
Coordinates 143591..143872 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q9I707
Locus tag MMZ77_RS00670 Protein ID WP_003112628.1
Coordinates 143869..144096 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MMZ77_RS00640 (MMZ77_00640) 138842..140191 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
MMZ77_RS00645 (MMZ77_00645) 140240..140926 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
MMZ77_RS00650 (MMZ77_00650) 141027..141761 + 735 WP_003117208.1 GntR family transcriptional regulator -
MMZ77_RS00655 (MMZ77_00655) 141941..142351 + 411 WP_003101225.1 aegerolysin family protein -
MMZ77_RS00660 (MMZ77_00660) 142383..143291 - 909 WP_003083769.1 LysR family transcriptional regulator -
MMZ77_RS00665 (MMZ77_00665) 143591..143872 - 282 WP_003121619.1 type II toxin-antitoxin system toxin ParE Toxin
MMZ77_RS00670 (MMZ77_00670) 143869..144096 - 228 WP_003112628.1 CopG family ribbon-helix-helix protein Antitoxin
MMZ77_RS00675 (MMZ77_00675) 144272..144892 - 621 WP_003101226.1 hypothetical protein -
MMZ77_RS00680 (MMZ77_00680) 144993..145493 + 501 WP_003101228.1 LEA type 2 family protein -
MMZ77_RS00685 (MMZ77_00685) 145566..145907 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
MMZ77_RS00690 (MMZ77_00690) 145989..147416 - 1428 WP_029610062.1 GABA permease -
MMZ77_RS00695 (MMZ77_00695) 147585..149078 - 1494 WP_241471435.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10492.22 Da        Isoelectric Point: 10.0435

>T237532 WP_003121619.1 NZ_CP093014:c143872-143591 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDTIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T237532 NZ_LR882496:3540821-3541165 [Mycobacterium tuberculosis variant microti]
TTGGCCGTGATCCTGCTCCCGCAGGTCGAACGGTGGTTCTTCGCGCTCAACAGGGATGCGATGGCCTCGGTCACCGGCGC
CATCGACCTGCTCGAAATGGAGGGGCCGACGTTGGGCCGCCCGGTGGTCGACAAAGTGAACGACTCAACGTTTCACAACA
TGAAGGAGCTGCGCCCCGCCGGCACCAGCATCCGGATCCTGTTCGCCTTCGACCCGGCCCGGCAGGCGATCCTGCTGCTG
GGCGGTGACAAGGCAGGCAACTGGAAACGCTGGTACGACAACAACATTCCAATCGCTGACCAGCGCTCCGAGAACTGGCT
GGCGAGCGAGCACGGAGGTGGATGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8568.64 Da        Isoelectric Point: 5.5740

>AT237532 WP_003112628.1 NZ_CP093014:c144096-143869 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHIEIEKRWGLQ

Download         Length: 228 bp

>AT237532 NZ_LR882496:3541162-3541491 [Mycobacterium tuberculosis variant microti]
ATGACCATGGCCCGCAACTGGCGTGACATTCGCGCCGATGCCGTCGCGCAGGGCCGCGTGGATCTGCAGCGGGCCGCCGT
GGCACGCGAGGAGATGCGCGATGCCGTCCTGGCGCACCGCCTGGCCGAGATCCGCAAGGCGCTAGGCCACGCACGTCAGG
CCGACGTCGCGGCGCTGATGGGGGTCTCTCAGGCCCGTGTCTCCAAGCTGGAGAGCGGCGACCTGTCCCACACCGAACTC
GGCACCCTGCAGGCCTACGTTGCCGCCCTGGGCGGGCACCTGCGCATCGTCGCTGAGTTCGGCGAAAATACTGTCGAGCT
GACCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A069QL22

Antitoxin

Source ID Structure
PDB 6XRW
AlphaFold DB Q9I707

References